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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Transdermal progesterone use in men
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<blockquote data-quote="JoeMatts" data-source="post: 192067" data-attributes="member: 41444"><p>I had/have very severe anxiety on trt, manifesting as a chronically pounding heart, racing thoughts, regular adrenaline surges and daily panic attacks — none of which were present pre-trt; all of which go away when I come off testosterone.</p><p></p><p>One thing that always correlated with the above is my serum progesterone. On trt, my progesterone immediately drops to undetectable levels, whereas pre-trt and whenever I've taken time off testosterone, my progesterone always returns back to the middle of the reference range. Something about exogenous testosterone and/or HPTA shutdown causes extreme suppression of my adrenals, which I used to believe was caused by the lack of LH - Crisler's 'backfilling the pathways' theory - but high-dose hcg does nothing to remedy it.</p><p></p><p>Based on the above, I decided to try sublingual progesterone @ 3mg before bed (one drop of progest-e). The anti-anxiety effects were extremely pronounced and I immediately felt calmer, which I believe can be attributed to the downstream conversion of progesterone to allopregnenolone, as the latter is a potent GABA-A agonist. However, after a week of use, I started to notice the development of spider veins all over my body, and my larger veins on my arms, legs and even genitals started to swell, expand, turn blue and twist, as if they were becoming varicose. I immediately ceased use of progesterone, and although the development of the veins stopped, the changes that were induced did not reverse. I have repeated this process multiple times now, with each attempt producing the same result: initiation of progesterone causes the veins to worsen; cessation of progesterone halts the progression, but does not reverse the changes.</p><p></p><p>There are papers which implicate progesterone in the development of varicose veins, but the same can be said for most hormones, including estrogen, testosterone, aldosterone and cortisol — unfortunately, there is no general consensus on what exactly causes them.</p><p></p><p>I wish I could use progesterone because I benefited greatly from it, but apart from the obvious aesthetic issue, I fear the development of severe venous insufficiency if I were to continue supplementation. FWIW, pregnenolone also causes the same issue.</p></blockquote><p></p>
[QUOTE="JoeMatts, post: 192067, member: 41444"] I had/have very severe anxiety on trt, manifesting as a chronically pounding heart, racing thoughts, regular adrenaline surges and daily panic attacks — none of which were present pre-trt; all of which go away when I come off testosterone. One thing that always correlated with the above is my serum progesterone. On trt, my progesterone immediately drops to undetectable levels, whereas pre-trt and whenever I've taken time off testosterone, my progesterone always returns back to the middle of the reference range. Something about exogenous testosterone and/or HPTA shutdown causes extreme suppression of my adrenals, which I used to believe was caused by the lack of LH - Crisler's 'backfilling the pathways' theory - but high-dose hcg does nothing to remedy it. Based on the above, I decided to try sublingual progesterone @ 3mg before bed (one drop of progest-e). The anti-anxiety effects were extremely pronounced and I immediately felt calmer, which I believe can be attributed to the downstream conversion of progesterone to allopregnenolone, as the latter is a potent GABA-A agonist. However, after a week of use, I started to notice the development of spider veins all over my body, and my larger veins on my arms, legs and even genitals started to swell, expand, turn blue and twist, as if they were becoming varicose. I immediately ceased use of progesterone, and although the development of the veins stopped, the changes that were induced did not reverse. I have repeated this process multiple times now, with each attempt producing the same result: initiation of progesterone causes the veins to worsen; cessation of progesterone halts the progression, but does not reverse the changes. There are papers which implicate progesterone in the development of varicose veins, but the same can be said for most hormones, including estrogen, testosterone, aldosterone and cortisol — unfortunately, there is no general consensus on what exactly causes them. I wish I could use progesterone because I benefited greatly from it, but apart from the obvious aesthetic issue, I fear the development of severe venous insufficiency if I were to continue supplementation. FWIW, pregnenolone also causes the same issue. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Transdermal progesterone use in men
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