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Evidence from in vitro studies is more convincing than no evidence, particularly in supporting general underlying principles. The direct interaction of DHT with aromatase and the estrogen receptor is basic biophysics, not overly subject to cross-species variation.




You mischaracterize what was said. This is about the relative activity of androgens and estrogens in men on TRT. While higher doses of testosterone do lead to higher levels of estradiol, the incremental increases can be attenuated with higher levels of DHT. At the same time, the estradiol is less effective when there's greater DHT interference at receptors. An additional mechanism is possible, in that work shows that "... DHT antagonism of estrogen ... appears to occur by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding." The sky's-the-limit crowd demonstrates the principle involved; symptoms of elevated estrogen are supposed to be addressed by raising the testosterone dose until resolution. Then there's the not-insignificant matter of the successful treatment of breast cancer with DHT and its derivatives, strongly contradicting the assertion that "serum levels do not have any physiological effect."




My places of education discouraged puerile ad hominem attacks as a means of persuasion. Yours?


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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