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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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<blockquote data-quote="RobRoy" data-source="post: 268965" data-attributes="member: 42893"><p>OMG! I would call this a very desperate attempt to make a point.</p><p>Lets see female rat cells, porcine granulosa cells, more rat cells, and then breast cancer cells. All IN VITRO CELL STUDIES!!!!! Most in rats and pigs!</p><p>You still don't get it because you really don't have any education in research or medicine.</p><p>Its Posts like yours that point out the ridiculousness of the information obtained on forums.</p><p>Let me make it real simple for you. These are all real interesting in vitro studies. I can give you literally hundreds or maybe even thousands of in vitro studies that are interesting and thought-provoking. But what you do if you want to know if DHT binds to the estrogen receptor in humans and inhibits estrogen action or if it directly affects aromatase then you give it to humans as part of a randomized controlled trial and see if it in fact does. Well guess what? We have done that over and over and over again. We've been raising DHT as well with testosterone for 85 years. So when you give it to humans does it block aromatase activity or does it bind to the estrogen receptor? The answer is no. When we give DHT it shuts down our production of testosterone therefore shutting down our production of estradiol.</p><p>So why don't you spend your time continuing to abstract surf which is the lowest of low and at least spend the time studying up on humans. You can leave all the in vitro animal studies alone. Focus on giving humans DHT or giving humans testosterone which raises DHT. What happens when we get transdermal or injectable testosterone? We raise the DHT. But wait a minute if we do that wouldn't that block the estrogen receptor or aromatase activity and therefore men's estradiol shouldn't be going up? But the estradiol does go up whenever we give testosterone the matter what method of delivery. When they give transdermal DHT and raise levels even above 700 or more it doesn't bind to the estrogen receptor or shut down aromatase activity? NO! It actually shuts down testosterone and shuts down estradiol due to the negative feedback on the hypothalamic pituitary axis</p><p></p><p>Thanks for sending me the in vitro cell studies and most amusingly using rat and porcine cells. I got a good laugh today thank you.</p><p>I will wait patiently on human studies</p><p>A super moderator of super misinformation. Just like in the past whenever I introduced scrotal cream, and the harm of blocking estradiol, it was met with responses just like yours today. Instead of really taking the time to read what's already been posted in the literature that's already been posted and say any hey man thank you for trying to educate us on what could be a confusing topic to a lot of men. But instead you abstract surf with in vitro Petri dish studies in rodents and pigs and apply that to humans. Do you understand how incorrect that is? If you want to know what DHT does to humans that take it, then look at the studies and see what it does. Just because it does it in a petri dish doesn't mean it's going to do it in vivo.</p></blockquote><p></p>
[QUOTE="RobRoy, post: 268965, member: 42893"] OMG! I would call this a very desperate attempt to make a point. Lets see female rat cells, porcine granulosa cells, more rat cells, and then breast cancer cells. All IN VITRO CELL STUDIES!!!!! Most in rats and pigs! You still don't get it because you really don't have any education in research or medicine. Its Posts like yours that point out the ridiculousness of the information obtained on forums. Let me make it real simple for you. These are all real interesting in vitro studies. I can give you literally hundreds or maybe even thousands of in vitro studies that are interesting and thought-provoking. But what you do if you want to know if DHT binds to the estrogen receptor in humans and inhibits estrogen action or if it directly affects aromatase then you give it to humans as part of a randomized controlled trial and see if it in fact does. Well guess what? We have done that over and over and over again. We've been raising DHT as well with testosterone for 85 years. So when you give it to humans does it block aromatase activity or does it bind to the estrogen receptor? The answer is no. When we give DHT it shuts down our production of testosterone therefore shutting down our production of estradiol. So why don't you spend your time continuing to abstract surf which is the lowest of low and at least spend the time studying up on humans. You can leave all the in vitro animal studies alone. Focus on giving humans DHT or giving humans testosterone which raises DHT. What happens when we get transdermal or injectable testosterone? We raise the DHT. But wait a minute if we do that wouldn't that block the estrogen receptor or aromatase activity and therefore men's estradiol shouldn't be going up? But the estradiol does go up whenever we give testosterone the matter what method of delivery. When they give transdermal DHT and raise levels even above 700 or more it doesn't bind to the estrogen receptor or shut down aromatase activity? NO! It actually shuts down testosterone and shuts down estradiol due to the negative feedback on the hypothalamic pituitary axis Thanks for sending me the in vitro cell studies and most amusingly using rat and porcine cells. I got a good laugh today thank you. I will wait patiently on human studies A super moderator of super misinformation. Just like in the past whenever I introduced scrotal cream, and the harm of blocking estradiol, it was met with responses just like yours today. Instead of really taking the time to read what's already been posted in the literature that's already been posted and say any hey man thank you for trying to educate us on what could be a confusing topic to a lot of men. But instead you abstract surf with in vitro Petri dish studies in rodents and pigs and apply that to humans. Do you understand how incorrect that is? If you want to know what DHT does to humans that take it, then look at the studies and see what it does. Just because it does it in a petri dish doesn't mean it's going to do it in vivo. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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