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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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<blockquote data-quote="tareload" data-source="post: 224021"><p>Post in thread 'Test prop time til peak' <a href="https://www.excelmale.com/forum/threads/test-prop-time-til-peak.24718/post-215888" target="_blank">Test prop time til peak</a></p><p></p><p>Post in thread 'Erection quality issues' <a href="https://www.excelmale.com/forum/threads/erection-quality-issues.20504/post-171961" target="_blank">Erection quality issues</a></p><p></p><p>The challenge with the Nieschlag data set (<a href="https://link.springer.com/chapter/10.1007/978-3-662-00814-0_6" target="_blank">1990</a>):</p><p></p><p></p><p>[ATTACH=full]21821[/ATTACH]</p><p></p><p>Using the original data points in the paper I calculate the following which fits what is reported in the paper:</p><p>[ATTACH=full]21822[/ATTACH]</p><p></p><p>Elimination half life = 21.6 hr</p><p>Absorption half life = 4.1 hr</p><p>Tmax = 12 hr</p><p></p><p></p><p>About 13% error on the model fit (RMSE).</p><p>[ATTACH=full]21823[/ATTACH]</p><p></p><p>However the first data point was collected at 14 hr.</p><p></p><p>Now, what if I add another data point hypothetically collected earlier in the time series:</p><p></p><p>[ATTACH=full]21825[/ATTACH]</p><p></p><p>Elimination half life = 22.4 hr</p><p>Absorption half life = 1.3 hr</p><p>Tmax = 5.6 hr</p><p></p><p>RMSE on the data fit is about the same.</p><p>[ATTACH=full]21826[/ATTACH]</p><p></p><p>That first data point (if taken earlier in time after injection) can drastically change estimated Tmax without changing estimated elimination half life very much:</p><p>[ATTACH=full]21827[/ATTACH]</p><p></p><p>Would also impact Cmax, AUC and MRT.</p></blockquote><p></p>
[QUOTE="tareload, post: 224021"] Post in thread 'Test prop time til peak' [URL='https://www.excelmale.com/forum/threads/test-prop-time-til-peak.24718/post-215888']Test prop time til peak[/URL] Post in thread 'Erection quality issues' [URL='https://www.excelmale.com/forum/threads/erection-quality-issues.20504/post-171961']Erection quality issues[/URL] The challenge with the Nieschlag data set ([URL='https://link.springer.com/chapter/10.1007/978-3-662-00814-0_6']1990[/URL]): [ATTACH type="full" alt="1652813002118.png"]21821[/ATTACH] Using the original data points in the paper I calculate the following which fits what is reported in the paper: [ATTACH type="full" alt="1652813042145.png"]21822[/ATTACH] Elimination half life = 21.6 hr Absorption half life = 4.1 hr Tmax = 12 hr About 13% error on the model fit (RMSE). [ATTACH type="full" alt="1652813226570.png"]21823[/ATTACH] However the first data point was collected at 14 hr. Now, what if I add another data point hypothetically collected earlier in the time series: [ATTACH type="full" alt="1652813382393.png"]21825[/ATTACH] Elimination half life = 22.4 hr Absorption half life = 1.3 hr Tmax = 5.6 hr RMSE on the data fit is about the same. [ATTACH type="full" alt="1652813465841.png"]21826[/ATTACH] That first data point (if taken earlier in time after injection) can drastically change estimated Tmax without changing estimated elimination half life very much: [ATTACH type="full" alt="1652813505660.png"]21827[/ATTACH] Would also impact Cmax, AUC and MRT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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