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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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<blockquote data-quote="RobRoy" data-source="post: 223648" data-attributes="member: 42893"><p>Studies of > 400? How about 700?</p><p>"In all of these studies, DHT treatment resulted in sustained increase serum DHT to high supra- physiologic levels of DHT [e.g., in the range of 700 ng/dL for up to 24 months "</p><p></p><p>Well first and foremost you have to understand the physiology and that DHT is a paracrine hormone and that the circulating levels have nothing to do with intra-tissue levels. But I do think raising it 10 times, 16 times, and 40 times normal will give you an idea if there's any harm. DHT has also been raised for decades in men on testosterone and yet no harm shown. DHT has been raised significantly with transdermal preparation's and once again no harm shown. So maybe you can show us we're raising DHT with testosterone or DHT itself has been shown to be harmful. Can you do that? In medicine when we say something might do something it means that it doesn't. In medicine when something has shown to do something we say that it does. It's like saying there might be men on Mars. There's not but I guess you could always say there might be…</p><p>There's also a saturation effect where DHT can only rise to a certain level and then it can rise no more. I think decades of raising DHT with testosterone has proven itself to be safe.</p><p>"Circulating levels of DHT in response to TRT do not correlate with those found in androgen-sensitive tissue (e.g., prostate, adipose, muscle) due to local regulatory mechanisms that tightly control intracellular androgen homeostasis. Observations from numerous clinical studies are consistent with current knowledge that androgen-sensitive tissues can self-regulate tissue DHT levels by downregulating its synthesis and upregulating metabolism during DHT excess or, conversely, upre- gulating synthesis and downregulating metabolism under conditions of T or DHT deprivation. We are reminded of Horton’s admonition some years ago when he concluded that blood levels of DHT provide only a hint of tissue levels and that DHT should be regarded as a paracrine hormone formed and acting primarily within target tissues".</p></blockquote><p></p>
[QUOTE="RobRoy, post: 223648, member: 42893"] Studies of > 400? How about 700? "In all of these studies, DHT treatment resulted in sustained increase serum DHT to high supra- physiologic levels of DHT [e.g., in the range of 700 ng/dL for up to 24 months " Well first and foremost you have to understand the physiology and that DHT is a paracrine hormone and that the circulating levels have nothing to do with intra-tissue levels. But I do think raising it 10 times, 16 times, and 40 times normal will give you an idea if there's any harm. DHT has also been raised for decades in men on testosterone and yet no harm shown. DHT has been raised significantly with transdermal preparation's and once again no harm shown. So maybe you can show us we're raising DHT with testosterone or DHT itself has been shown to be harmful. Can you do that? In medicine when we say something might do something it means that it doesn't. In medicine when something has shown to do something we say that it does. It's like saying there might be men on Mars. There's not but I guess you could always say there might be… There's also a saturation effect where DHT can only rise to a certain level and then it can rise no more. I think decades of raising DHT with testosterone has proven itself to be safe. "Circulating levels of DHT in response to TRT do not correlate with those found in androgen-sensitive tissue (e.g., prostate, adipose, muscle) due to local regulatory mechanisms that tightly control intracellular androgen homeostasis. Observations from numerous clinical studies are consistent with current knowledge that androgen-sensitive tissues can self-regulate tissue DHT levels by downregulating its synthesis and upregulating metabolism during DHT excess or, conversely, upre- gulating synthesis and downregulating metabolism under conditions of T or DHT deprivation. We are reminded of Horton’s admonition some years ago when he concluded that blood levels of DHT provide only a hint of tissue levels and that DHT should be regarded as a paracrine hormone formed and acting primarily within target tissues". [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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