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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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<blockquote data-quote="madman" data-source="post: 161056" data-attributes="member: 13851"><p>True if we were to base that statement off of the previous understanding of SHBG:T binding which was flawed!</p><p></p><p>Due to the newer research/understanding of SHBG:T binding.....even in cases of higher SHBG an extremely high TT level is not needed to achieve a healthy FT.</p><p></p><p></p><p>[0387] <span style="color: rgb(44, 130, 201)">Relation between Percent FT with Total Testosterone and </span><span style="color: rgb(184, 49, 47)">SHBG. <strong>Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations </strong></span><span style="color: rgb(251, 160, 38)"><strong>without getting saturated.</strong></span> <span style="color: rgb(44, 130, 201)">Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.</span> <span style="color: rgb(26, 188, 156)">In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.</span> <span style="color: rgb(44, 130, 201)">Furthermore, as </span><span style="color: rgb(184, 49, 47)"><strong>SHBG concentrations increase, percent FT</strong></span><span style="color: rgb(44, 130, 201)"> calculated using our new model </span><span style="color: rgb(184, 49, 47)"><strong>shows only a modest decline</strong></span> <span style="color: rgb(26, 188, 156)">in contrast to the marked decline in percent FT calculated using Vermeulen's equation. </span></p><p></p><p></p><p>*<span style="color: rgb(184, 49, 47)"><strong>Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations </strong></span><span style="color: rgb(251, 160, 38)"><strong>without getting saturated.</strong></span></p><p></p><p></p><p></p><p>FT calculated using the newer TruT model</p><p></p><p>Even with a TT 1600 ng/dL and an absurdly high SHBG 90 nmol/L, Albumin 4.3 g/dL (mean).....ones FT levels would be very high 51.49 ng/dL.</p><p>[ATTACH=full]8474[/ATTACH]</p><p></p><p></p><p>Regarding the newer TruT calculated method (shown to on par with results obtained by the gold standard Equilibrium Dialysis)</p><p></p><p>Even if you are one that has no interest in using calculated methods and you want to use the direct assay testing than one would need to have their FT tested using the most accurate method such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>Than you would still even see even if one had a very high TT 1500+ along with very high SHBG that ones FT levels would be very high.</p><p></p><p>Again unfortunately most are still using/relying on the piss poor inaccurate direct immunoassay/tracer analogue methods or using the outdated linear law-of-mass action calculated Vermeulen method which is based on a flawed model and has been show to underestimated FT levels by as much as 40% (when compared to the gold standard Equilibrium Dialysis method).</p><p></p><p>The newer research/understanding of SHBG:T binding changes the whole landscape.</p><p></p><p>Even when one has higher SHBG as long as a high enough TT is attained than it will result in a healthy FT and extremely high TT levels are not needed to achieve such.</p><p></p><p>As I stated many time before a TT 1000 ng/dL, SHBG 70 nmol/L, Albumin 4.3 g/dL would have ones FT levels in the at the top end of the range 31.30 ng/dL (reference range 16-31).....so much for needing a TT 1500-1600 ng/dL to achieve such!</p><p></p><p>Now if the same man with a high SHBG 70 nmol/L wanted to achieve very high FT levels as in 50+ ng/dL than a TT of 1500-1600 ng/dL would be needed.</p><p></p><p>I am just trying to stress the point that in cases of one having higher SHBG that an EXTREMELY HIGH TT is in no way needed to achieve a HEALTHY FT 30-30+ ng/dL.</p><p></p><p>I could care less whether one wants to run an extremely high TT 1600-2000- ng/dL with an extremely high FT of 50-60+ ng/dL.....to each his own.....do what is in your own best interest!</p><p></p><p>But everyone needs to understand the importance regarding the new research of SHBG:T binding and get it in their heads that even with high SHBG an extremely high TT is in no way needed to achieve a healthy FT level.</p><p></p><p>When one has very high SHBG and average TT (<600 or 600-700 ng/dL) levels than and only than would FT levels be low/sub-par.</p></blockquote><p></p>
[QUOTE="madman, post: 161056, member: 13851"] True if we were to base that statement off of the previous understanding of SHBG:T binding which was flawed! Due to the newer research/understanding of SHBG:T binding.....even in cases of higher SHBG an extremely high TT level is not needed to achieve a healthy FT. [0387] [COLOR=rgb(44, 130, 201)]Relation between Percent FT with Total Testosterone and [/COLOR][COLOR=rgb(184, 49, 47)]SHBG. [B]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations [/B][/COLOR][COLOR=rgb(251, 160, 38)][B]without getting saturated.[/B][/COLOR] [COLOR=rgb(44, 130, 201)]Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations.[/COLOR] [COLOR=rgb(26, 188, 156)]In contrast, the Vermeulen's equation suggests a negative relation between percent FT and total testosterone.[/COLOR] [COLOR=rgb(44, 130, 201)]Furthermore, as [/COLOR][COLOR=rgb(184, 49, 47)][B]SHBG concentrations increase, percent FT[/B][/COLOR][COLOR=rgb(44, 130, 201)] calculated using our new model [/COLOR][COLOR=rgb(184, 49, 47)][B]shows only a modest decline[/B][/COLOR] [COLOR=rgb(26, 188, 156)]in contrast to the marked decline in percent FT calculated using Vermeulen's equation. [/COLOR] *[COLOR=rgb(184, 49, 47)][B]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations [/B][/COLOR][COLOR=rgb(251, 160, 38)][B]without getting saturated.[/B][/COLOR] FT calculated using the newer TruT model Even with a TT 1600 ng/dL and an absurdly high SHBG 90 nmol/L, Albumin 4.3 g/dL (mean).....ones FT levels would be very high 51.49 ng/dL. [ATTACH=full]8474[/ATTACH] Regarding the newer TruT calculated method (shown to on par with results obtained by the gold standard Equilibrium Dialysis) Even if you are one that has no interest in using calculated methods and you want to use the direct assay testing than one would need to have their FT tested using the most accurate method such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best). Than you would still even see even if one had a very high TT 1500+ along with very high SHBG that ones FT levels would be very high. Again unfortunately most are still using/relying on the piss poor inaccurate direct immunoassay/tracer analogue methods or using the outdated linear law-of-mass action calculated Vermeulen method which is based on a flawed model and has been show to underestimated FT levels by as much as 40% (when compared to the gold standard Equilibrium Dialysis method). The newer research/understanding of SHBG:T binding changes the whole landscape. Even when one has higher SHBG as long as a high enough TT is attained than it will result in a healthy FT and extremely high TT levels are not needed to achieve such. As I stated many time before a TT 1000 ng/dL, SHBG 70 nmol/L, Albumin 4.3 g/dL would have ones FT levels in the at the top end of the range 31.30 ng/dL (reference range 16-31).....so much for needing a TT 1500-1600 ng/dL to achieve such! Now if the same man with a high SHBG 70 nmol/L wanted to achieve very high FT levels as in 50+ ng/dL than a TT of 1500-1600 ng/dL would be needed. I am just trying to stress the point that in cases of one having higher SHBG that an EXTREMELY HIGH TT is in no way needed to achieve a HEALTHY FT 30-30+ ng/dL. I could care less whether one wants to run an extremely high TT 1600-2000- ng/dL with an extremely high FT of 50-60+ ng/dL.....to each his own.....do what is in your own best interest! But everyone needs to understand the importance regarding the new research of SHBG:T binding and get it in their heads that even with high SHBG an extremely high TT is in no way needed to achieve a healthy FT level. When one has very high SHBG and average TT (<600 or 600-700 ng/dL) levels than and only than would FT levels be low/sub-par. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Trans scrotal testosterone cream application is a game changer
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