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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Tramadol & HCG
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<blockquote data-quote="Nelson Vergel" data-source="post: 277938" data-attributes="member: 3"><p>Based on the search results provided, here is a summary of the effects of tramadol on testosterone levels:</p><p></p><p>## Key Findings</p><p></p><p>- Tramadol administration has a negative effect on testosterone levels. Several studies have found that as the dose and duration of tramadol use increases, testosterone levels decrease significantly[1][2][3][4].</p><p></p><p>- The influence of tramadol on testosterone levels is dose-dependent. Higher doses of tramadol lead to more pronounced reductions in testosterone[1][2].</p><p></p><p>- Tramadol can cause hypogonadism, leading to symptoms like loss of libido, infertility, fatigue, depression, and impotence in men[2].</p><p></p><p>- The mechanism by which tramadol reduces testosterone appears to be through inhibition of enzymes involved in steroid hormone biosynthesis, as well as induction of oxidative stress in the testes[4].</p><p></p><p>- Concomitant administration of antioxidants like selenium and garlic can help mitigate the adverse effects of tramadol on testosterone and other reproductive parameters[4].</p><p></p><p>In summary, the available evidence clearly indicates that tramadol has a gonadotoxic effect, leading to a dose-dependent decrease in testosterone levels and associated sexual dysfunction. Clinicians should be aware of this potential side effect when prescribing tramadol, especially for prolonged durations[1][2][3][4].</p><p></p><p>Citations:</p><p>[1] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881065/" target="_blank">Gonadotoxic effect of tramadol administration: A prospective controlled study</a></p><p>[2] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247366/" target="_blank">Effect of tramadol dependence on male sexual dysfunction</a></p><p>[3] <a href="https://mecp.springeropen.com/articles/10.1186/s43045-020-00027-y" target="_blank">Male Sex Hormone affection in patients with Tramadol dependance - Middle East Current Psychiatry</a></p><p>[4] <a href="https://www.nature.com/articles/s41598-022-16862-4" target="_blank">Antioxidants (selenium and garlic) alleviated the adverse effects of tramadol on the reproductive system and oxidative stress markers in male rabbits - Scientific Reports</a></p><p>[5] <a href="https://www.aruplab.com/news/04-18-17" target="_blank">Is Treating Your Pain Depleting Your Sex Hormones?</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 277938, member: 3"] Based on the search results provided, here is a summary of the effects of tramadol on testosterone levels: ## Key Findings - Tramadol administration has a negative effect on testosterone levels. Several studies have found that as the dose and duration of tramadol use increases, testosterone levels decrease significantly[1][2][3][4]. - The influence of tramadol on testosterone levels is dose-dependent. Higher doses of tramadol lead to more pronounced reductions in testosterone[1][2]. - Tramadol can cause hypogonadism, leading to symptoms like loss of libido, infertility, fatigue, depression, and impotence in men[2]. - The mechanism by which tramadol reduces testosterone appears to be through inhibition of enzymes involved in steroid hormone biosynthesis, as well as induction of oxidative stress in the testes[4]. - Concomitant administration of antioxidants like selenium and garlic can help mitigate the adverse effects of tramadol on testosterone and other reproductive parameters[4]. In summary, the available evidence clearly indicates that tramadol has a gonadotoxic effect, leading to a dose-dependent decrease in testosterone levels and associated sexual dysfunction. Clinicians should be aware of this potential side effect when prescribing tramadol, especially for prolonged durations[1][2][3][4]. Citations: [1] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881065/"]Gonadotoxic effect of tramadol administration: A prospective controlled study[/URL] [2] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247366/"]Effect of tramadol dependence on male sexual dysfunction[/URL] [3] [URL="https://mecp.springeropen.com/articles/10.1186/s43045-020-00027-y"]Male Sex Hormone affection in patients with Tramadol dependance - Middle East Current Psychiatry[/URL] [4] [URL="https://www.nature.com/articles/s41598-022-16862-4"]Antioxidants (selenium and garlic) alleviated the adverse effects of tramadol on the reproductive system and oxidative stress markers in male rabbits - Scientific Reports[/URL] [5] [URL="https://www.aruplab.com/news/04-18-17"]Is Treating Your Pain Depleting Your Sex Hormones?[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Tramadol & HCG
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