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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Tramadol Abuse: Impact on Sperm Quality, T-Levels, Prolactin
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<blockquote data-quote="CoastWatcher" data-source="post: 107863" data-attributes="member: 2624"><p>Tramadol, a Schedule IV Controlled Substance in the United States, is an abused opiate - particularly in the Middle East. A small study was undertaken to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n = 30) to age-matched control (n = 30). </p><p></p><ul> <li data-xf-list-type="ul"><strong>Abusers had significantly low percentages of sperm motility, normal forms and vitality compared with control (95% CI -40.7 to -19.3, -13.5 to -9.3 and -31.9 to -9.7 respectively).</strong></li> <li data-xf-list-type="ul"><strong>Hypoandrogenism (95% CI -4.5 to -2.8), hyperprolactinaemia (CI (95%) 4.9 to 9.4) and hypergonadotropinaemia (95% CI 2.9 to 7.2 for FSH and 2.0 to 7.8 for LH) were observed in tramadol abusers vs controls. </strong></li> <li data-xf-list-type="ul"><strong>Smokers (26 of 30), concurrently abusing other drugs (11 of 30) and asymptomatic leucocytospermic (15 of 30) patients subgroups significantly abused tramadol beyond 3 years (p = .02, <.001, = .03 respectively) and in excess >450 mg/day (p = .02, = .01, = .005 respectively). Progressive motility (a + b%) was significantly low in young men <25 years old (p = .03) subgroup.</strong></li> <li data-xf-list-type="ul"><em><strong>Tramadol abuse is associated with poor sperm quality, hyperprolactinaemia and hypergonadotropic hypogonadism. We recommend semen analysis for tramadol long-intakes, question sperm donors and follow-up studies to prevent and reverse tramadol-induced testicular damage.</strong></em></li> </ul><p>"Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men," <em>Andrologia, 2018, <a href="https://www.ncbi.nlm.nih.gov/m/pubmed/29781510/" target="_blank">https://www.ncbi.nlm.nih.gov/m/pubmed/29781510/</a></em></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 107863, member: 2624"] Tramadol, a Schedule IV Controlled Substance in the United States, is an abused opiate - particularly in the Middle East. A small study was undertaken to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n = 30) to age-matched control (n = 30). [LIST] [*][B]Abusers had significantly low percentages of sperm motility, normal forms and vitality compared with control (95% CI -40.7 to -19.3, -13.5 to -9.3 and -31.9 to -9.7 respectively).[/B] [*][B]Hypoandrogenism (95% CI -4.5 to -2.8), hyperprolactinaemia (CI (95%) 4.9 to 9.4) and hypergonadotropinaemia (95% CI 2.9 to 7.2 for FSH and 2.0 to 7.8 for LH) were observed in tramadol abusers vs controls. [/B] [*][B]Smokers (26 of 30), concurrently abusing other drugs (11 of 30) and asymptomatic leucocytospermic (15 of 30) patients subgroups significantly abused tramadol beyond 3 years (p = .02, <.001, = .03 respectively) and in excess >450 mg/day (p = .02, = .01, = .005 respectively). Progressive motility (a + b%) was significantly low in young men <25 years old (p = .03) subgroup.[/B] [*][I][B]Tramadol abuse is associated with poor sperm quality, hyperprolactinaemia and hypergonadotropic hypogonadism. We recommend semen analysis for tramadol long-intakes, question sperm donors and follow-up studies to prevent and reverse tramadol-induced testicular damage.[/B][/I] [/LIST] "Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men," [I]Andrologia, 2018, [URL]https://www.ncbi.nlm.nih.gov/m/pubmed/29781510/[/URL][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Tramadol Abuse: Impact on Sperm Quality, T-Levels, Prolactin
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