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General Health & Fitness
Health & Wellness
Topical Nitric oxide-releasing PDE5 inhibitor for wound healing indications.
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<blockquote data-quote="madman" data-source="post: 189974" data-attributes="member: 13851"><p><strong>Fig. 2. <span style="color: rgb(184, 49, 47)">TOP-N53, a highly potent NO-releasing PDE5 inhibitor elevates intracellular cGMP by a synergistic interaction between an enhanced cGMP synthesis secondary to stimulation of sGC by the released NO, and reduced cGMP degradation caused by inhibition of PDE5 by TOP-N53 and its active and more potent metabolite, TOP-52 in cells where sGC and PDE5 are expressed. Both NO and TOP-52 are products of the ‘bioactivation’ of TOP-N53. </span></strong></p><p>[ATTACH=full]11365[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 189974, member: 13851"] [B]Fig. 2. [COLOR=rgb(184, 49, 47)]TOP-N53, a highly potent NO-releasing PDE5 inhibitor elevates intracellular cGMP by a synergistic interaction between an enhanced cGMP synthesis secondary to stimulation of sGC by the released NO, and reduced cGMP degradation caused by inhibition of PDE5 by TOP-N53 and its active and more potent metabolite, TOP-52 in cells where sGC and PDE5 are expressed. Both NO and TOP-52 are products of the ‘bioactivation’ of TOP-N53. [/COLOR][/B] [ATTACH type="full"]11365[/ATTACH] [/QUOTE]
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General Health & Fitness
Health & Wellness
Topical Nitric oxide-releasing PDE5 inhibitor for wound healing indications.
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