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General Health & Fitness
Health & Wellness
Topical Nitric oxide-releasing PDE5 inhibitor for wound healing indications.
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<blockquote data-quote="madman" data-source="post: 189971" data-attributes="member: 13851"><p><strong>Fig. 1. <span style="color: rgb(184, 49, 47)">Endothelial dysfunction and regulation of cGMP.</span> In vascular smooth muscle cells intracellular cGMP is controlled by the balance between synthesis <span style="color: rgb(184, 49, 47)">(for example by sGC)</span> and degradation<span style="color: rgb(184, 49, 47)"> (for example by PDE5)</span>. <span style="color: rgb(44, 130, 201)">Endothelial dysfunction can be attributed to impaired endogenous NO release from endothelial cells resulting in reduced sGC activation and less cGMP in vascular smooth muscle cells. Finally, impaired microcirculation may ensue. Consequently, the supply of oxygen and nutrients as well as waste elimination would be compromised that deteriorates tissue regeneration and delays wound healing.</span></strong> </p><p>[ATTACH=full]11362[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 189971, member: 13851"] [B]Fig. 1. [COLOR=rgb(184, 49, 47)]Endothelial dysfunction and regulation of cGMP.[/COLOR] In vascular smooth muscle cells intracellular cGMP is controlled by the balance between synthesis [COLOR=rgb(184, 49, 47)](for example by sGC)[/COLOR] and degradation[COLOR=rgb(184, 49, 47)] (for example by PDE5)[/COLOR]. [COLOR=rgb(44, 130, 201)]Endothelial dysfunction can be attributed to impaired endogenous NO release from endothelial cells resulting in reduced sGC activation and less cGMP in vascular smooth muscle cells. Finally, impaired microcirculation may ensue. Consequently, the supply of oxygen and nutrients as well as waste elimination would be compromised that deteriorates tissue regeneration and delays wound healing.[/COLOR][/B][COLOR=rgb(44, 130, 201)] [/COLOR] [ATTACH type="full"]11362[/ATTACH] [/QUOTE]
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General Health & Fitness
Health & Wellness
Topical Nitric oxide-releasing PDE5 inhibitor for wound healing indications.
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