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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Topical minoxidil fortified with finasteride
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<blockquote data-quote="Sides" data-source="post: 158091" data-attributes="member: 31749"><p>Especially since your goal right now is to get your wife pregnant, I would suggest that you play it safe, and avoid the use of any 5-Alpha-Reductase inhibitors, even topical, until after you get your wife pregnant.</p><p></p><p>The 5-Alpha-Reductase inhibitors all have fertility risks, not to mention risks with erectile dysfunction, and Finasteride in particular does reduce sperm counts in some men.</p><p></p><p><a href="https://www.fertstert.org/article/S0015-0282(13)02786-6/fulltext" target="_blank">https://www.fertstert.org/article/S0015-0282(13)02786-6/fulltext</a> </p><p></p><p>"Finasteride, even at low doses, may cause reduced sperm counts in some men. In this population, counts improved dramatically for the majority of men after finasteride discontinuation. The hormone parameters, sperm motility, and sperm morphology were unchanged after cessation. Finasteride should be discontinued in subfertile men with oligospermia, and used with caution in men who desire fertility."</p><p></p><p>"Low-dose finasteride does appear to exert a negative effect on fertility on some men. When we discontinued finasteride treatment in our patients, we found a significant increase in sperm count (an average 11.6-fold increase) (<a href="https://www.fertstert.org/article/S0015-0282(13)02786-6/fulltext#tbl1" target="_blank">Table 1</a>), which was more notable in men with severe oligospermia at initial assessment. Men with a sperm concentration <5 M/mL had an average increase in their sperm concentration of 22.06 M/mL, and those with sperm concentration 5–15 M/mL had an average increase in their sperm concentration of 138.87 M/mL. Men with a sperm concentration >15 M/mL had an average increase in their sperm concentration of 95.28 M/mL."</p><p></p><p>"Our study indicates that finasteride is associated with subfertility in some men and that the adverse effect of finasteride is reversible for most of the men who present with infertility. We suggest that in infertile men with oligospermia or azoospermia using finasteride, even at the low dose of 1 mg for androgenic alopecia, the drug should be discontinued. The discontinuation of finasteride may not bring the sperm parameters to levels where a spontaneous pregnancy is likely, but it may lead to improvement in semen parameters that will allow for a less invasive fertility therapy (intrauterine insemination versus intracytoplasmic sperm injection). In addition, caution and appropriate counseling should be exercised when these drugs are given to men of reproductive age who desire fertility."</p></blockquote><p></p>
[QUOTE="Sides, post: 158091, member: 31749"] Especially since your goal right now is to get your wife pregnant, I would suggest that you play it safe, and avoid the use of any 5-Alpha-Reductase inhibitors, even topical, until after you get your wife pregnant. The 5-Alpha-Reductase inhibitors all have fertility risks, not to mention risks with erectile dysfunction, and Finasteride in particular does reduce sperm counts in some men. [URL]https://www.fertstert.org/article/S0015-0282(13)02786-6/fulltext[/URL] "Finasteride, even at low doses, may cause reduced sperm counts in some men. In this population, counts improved dramatically for the majority of men after finasteride discontinuation. The hormone parameters, sperm motility, and sperm morphology were unchanged after cessation. Finasteride should be discontinued in subfertile men with oligospermia, and used with caution in men who desire fertility." "Low-dose finasteride does appear to exert a negative effect on fertility on some men. When we discontinued finasteride treatment in our patients, we found a significant increase in sperm count (an average 11.6-fold increase) ([URL='https://www.fertstert.org/article/S0015-0282(13)02786-6/fulltext#tbl1']Table 1[/URL]), which was more notable in men with severe oligospermia at initial assessment. Men with a sperm concentration <5 M/mL had an average increase in their sperm concentration of 22.06 M/mL, and those with sperm concentration 5–15 M/mL had an average increase in their sperm concentration of 138.87 M/mL. Men with a sperm concentration >15 M/mL had an average increase in their sperm concentration of 95.28 M/mL." "Our study indicates that finasteride is associated with subfertility in some men and that the adverse effect of finasteride is reversible for most of the men who present with infertility. We suggest that in infertile men with oligospermia or azoospermia using finasteride, even at the low dose of 1 mg for androgenic alopecia, the drug should be discontinued. The discontinuation of finasteride may not bring the sperm parameters to levels where a spontaneous pregnancy is likely, but it may lead to improvement in semen parameters that will allow for a less invasive fertility therapy (intrauterine insemination versus intracytoplasmic sperm injection). In addition, caution and appropriate counseling should be exercised when these drugs are given to men of reproductive age who desire fertility." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Topical minoxidil fortified with finasteride
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