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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Too Many Red Blood Cells or Platelets Stall Blood Flow in Cerebral Capillaries
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<blockquote data-quote="Nelson Vergel" data-source="post: 163320" data-attributes="member: 3"><p>The demonstration by Dr. Santisakultarm and colleagues of stalled blood flow in increased percentages of cerebral capillaries in PV and ET provides a mechanism other than thrombosis for focal cerebral hypoxia and subsequent microinfarction. The abrupt, spontaneous resolution of these capillary stalls with re-established rapid blood flow may explain the frequent but transient central nervous system symptoms including headaches, dizziness, vision loss, dysphasia, and focal paresis that are associated with PV, ET, and secondary polycythemia. Stalled blood flow in cerebral capillaries may also help explain how increased hematocrit is associated with reduced reperfusion and enhanced infarct size on serial MRIs following ischemic strokes.7 Therefore, stalled cerebral capillary blood flow may play a role in microinfarcts and in exacerbation of ischemic damage from compromised blood flow in larger cerebral vessels.</p><p></p><p><a href="https://www.hematology.org/Thehematologist/Diffusion/3911.aspx" target="_blank">Santisakultarm TP, Paduano CQ, Stokol T, et al. Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. J Thromb Haemost. 2014;12:2120-2130.</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 163320, member: 3"] The demonstration by Dr. Santisakultarm and colleagues of stalled blood flow in increased percentages of cerebral capillaries in PV and ET provides a mechanism other than thrombosis for focal cerebral hypoxia and subsequent microinfarction. The abrupt, spontaneous resolution of these capillary stalls with re-established rapid blood flow may explain the frequent but transient central nervous system symptoms including headaches, dizziness, vision loss, dysphasia, and focal paresis that are associated with PV, ET, and secondary polycythemia. Stalled blood flow in cerebral capillaries may also help explain how increased hematocrit is associated with reduced reperfusion and enhanced infarct size on serial MRIs following ischemic strokes.7 Therefore, stalled cerebral capillary blood flow may play a role in microinfarcts and in exacerbation of ischemic damage from compromised blood flow in larger cerebral vessels. [URL='https://www.hematology.org/Thehematologist/Diffusion/3911.aspx']Santisakultarm TP, Paduano CQ, Stokol T, et al. Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. J Thromb Haemost. 2014;12:2120-2130.[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Too Many Red Blood Cells or Platelets Stall Blood Flow in Cerebral Capillaries
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