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General Health & Fitness
Health & Wellness
Tirzepatide Once Weekly for the Treatment of Obesity
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<blockquote data-quote="madman" data-source="post: 229925" data-attributes="member: 13851"><p><strong>Figure 1. <u>Effect of Once-Weekly Tirzepatide, as Compared with Placebo, on Body Weight. Least-squares means are presented unless otherwise noted</u>. <u>Panel A</u> shows the percent change in body weight from baseline to week 72, derived from an analysis of the covariance model for the treatment-regimen estimand (TRE). <u>Panel B</u> shows the percent change in body weight according to weeks since randomization, derived from a mixed model for repeated measures (MMRM) analysis for the efficacy estimand; week 72 estimates for the treatment-regimen estimand are also shown. <u>Panels C and D</u> show the percentages of participants who had weight reductions of at least 5%, 10%, 15%, 20%, and 25% from baseline to week 72. For <u>Panel C</u>, the percentage was calculated with the use of Rubin’s rules by combining the percentages of participants who met the target in imputed data sets. Missing values at week 72 were imputed with MMRM if the missingness was due solely to Covid-19 and with multiple imputations if the missingness was not due to Covid-19. For <u>Panel D</u>, the percentage of participants who met weight-reduction targets was obtained by dividing the number of participants reaching respective goals at week 72 by the number of participants with a baseline value and at least one nonmissing post-baseline value. Missing values at week 72 were imputed from MMRM analysis. I bars indicate 95% confidence intervals.</strong></p><p><strong>[ATTACH=full]24508[/ATTACH]</strong></p><p><strong>[ATTACH=full]24509[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 229925, member: 13851"] [B]Figure 1. [U]Effect of Once-Weekly Tirzepatide, as Compared with Placebo, on Body Weight. Least-squares means are presented unless otherwise noted[/U]. [U]Panel A[/U] shows the percent change in body weight from baseline to week 72, derived from an analysis of the covariance model for the treatment-regimen estimand (TRE). [U]Panel B[/U] shows the percent change in body weight according to weeks since randomization, derived from a mixed model for repeated measures (MMRM) analysis for the efficacy estimand; week 72 estimates for the treatment-regimen estimand are also shown. [U]Panels C and D[/U] show the percentages of participants who had weight reductions of at least 5%, 10%, 15%, 20%, and 25% from baseline to week 72. For [U]Panel C[/U], the percentage was calculated with the use of Rubin’s rules by combining the percentages of participants who met the target in imputed data sets. Missing values at week 72 were imputed with MMRM if the missingness was due solely to Covid-19 and with multiple imputations if the missingness was not due to Covid-19. For [U]Panel D[/U], the percentage of participants who met weight-reduction targets was obtained by dividing the number of participants reaching respective goals at week 72 by the number of participants with a baseline value and at least one nonmissing post-baseline value. Missing values at week 72 were imputed from MMRM analysis. I bars indicate 95% confidence intervals. [ATTACH type="full"]24508[/ATTACH] [ATTACH type="full"]24509[/ATTACH][/B] [/QUOTE]
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General Health & Fitness
Health & Wellness
Tirzepatide Once Weekly for the Treatment of Obesity
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