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I haven't read through the whole thread but, and maybe its been suggested, that you go off of T.  Let it clear out of your system.  There are men who don't respond to T in the way a doctor would expect and likely does have something to do with HPA malfunction.  I believe Dr. Crisler had some such patients.  I'm one of them, too, though I keep taking T because I believe I generally function better on it. Maybe I'm wrong.  I've been all over the dosing protocols and amounts.  The only one that brought some improvement, energywise and sexually, was 100 mg, IM, E5D. 


Someone on here had addressed the issue by suggesting varying the protocol and dose every few weeks, including a break from T.   I've said it many times that there are men who are truly outliers and do better on dosing protocols that are considered ineffective or outdated, such as a large dose every 2 weeks or even 100 to 150 every 2 weeks to men doing 10 mg, daily. 


Don't give up.  Regardless of lab numbers, even if they're in the toilet; if that's where you feel good and sexually function, no point in trying to reinvent the wheel!


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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