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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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<blockquote data-quote="Cataceous" data-source="post: 256641" data-attributes="member: 38109"><p>There are at least a couple approaches to this. If you're still experimenting with the ester ratio then it could make sense to draw the esters separately into the same syringe for each injection. However, if you have settled on the ester ratio then it is less work to blend the two esters in a separate sterile vial, so that a single draw is needed for each injection. There's also less blunting of the syringe needle with a single draw.</p><p></p><p>I'll make one change in your example, which is setting the concentration of T propionate to 100 mg/mL, because this is far more common. You would draw 10 mg of T enanthate (TE) (0.05 mL) and then draw 6 mg of T propionate (TP) (0.06 mL), so that your syringe contains a total of 0.11 mL, which would be 11 units in a U-100 insulin syringe.</p><p></p><p>If you want to keep the vial pressures equalized then it's good to alternate which vial is used first, and inject double the withdrawal volume of air in the first vial and none in the second. That is, for the first injection you would inject 10 units of air before withdrawing 5 units of TE, and then immediately draw the 6 units of TP. For the second injection you would inject 12 units of air into the TP vial before drawing the 6 units, and then immediately draw the 5 units of TE. For the third and fourth injections you duplicate the first and second injections, and so on.</p><p></p><p>Once the long-term ester ratio is chosen then you can fill a separate vial with the ester blend. Note that in theory it is possible to have slightly different pharmacokinetics with a blend versus unmixed esters in the same syringe. However, I have done both and didn't notice any qualitative or quantitative differences when I made the switch. Suppose you want to be conservative and mix 20 days worth at a time. If you maintain the ratio of 10 mg TE to 6 mg TP then into a new sterile vial you would inject 200 mg of TE (1 mL) and 120 mg of TP (1.2 mL). The dose would be the same total volume, 0.11 mL or 11 units.</p><p></p><p>There's a further complication, in that if you do the above then you will be increasing your already elevated testosterone dose. The 16 mg TE is giving you 11.5 mg T. The blend increases this to 12.2 mg T. This is because TP contains more testosterone by weight than TE. The shorter half-life of TP also means that peak serum testosterone will be considerably higher than with TE alone. As a result I typically suggest a dose reduction of at least 20%, which puts you at 8 mg TE and 5 mg TP.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 256641, member: 38109"] There are at least a couple approaches to this. If you're still experimenting with the ester ratio then it could make sense to draw the esters separately into the same syringe for each injection. However, if you have settled on the ester ratio then it is less work to blend the two esters in a separate sterile vial, so that a single draw is needed for each injection. There's also less blunting of the syringe needle with a single draw. I'll make one change in your example, which is setting the concentration of T propionate to 100 mg/mL, because this is far more common. You would draw 10 mg of T enanthate (TE) (0.05 mL) and then draw 6 mg of T propionate (TP) (0.06 mL), so that your syringe contains a total of 0.11 mL, which would be 11 units in a U-100 insulin syringe. If you want to keep the vial pressures equalized then it's good to alternate which vial is used first, and inject double the withdrawal volume of air in the first vial and none in the second. That is, for the first injection you would inject 10 units of air before withdrawing 5 units of TE, and then immediately draw the 6 units of TP. For the second injection you would inject 12 units of air into the TP vial before drawing the 6 units, and then immediately draw the 5 units of TE. For the third and fourth injections you duplicate the first and second injections, and so on. Once the long-term ester ratio is chosen then you can fill a separate vial with the ester blend. Note that in theory it is possible to have slightly different pharmacokinetics with a blend versus unmixed esters in the same syringe. However, I have done both and didn't notice any qualitative or quantitative differences when I made the switch. Suppose you want to be conservative and mix 20 days worth at a time. If you maintain the ratio of 10 mg TE to 6 mg TP then into a new sterile vial you would inject 200 mg of TE (1 mL) and 120 mg of TP (1.2 mL). The dose would be the same total volume, 0.11 mL or 11 units. There's a further complication, in that if you do the above then you will be increasing your already elevated testosterone dose. The 16 mg TE is giving you 11.5 mg T. The blend increases this to 12.2 mg T. This is because TP contains more testosterone by weight than TE. The shorter half-life of TP also means that peak serum testosterone will be considerably higher than with TE alone. As a result I typically suggest a dose reduction of at least 20%, which puts you at 8 mg TE and 5 mg TP. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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