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It is more common to have injection site reactions with propionate than with the longer esters. What I have found is that Empower Pharmacy's propionate is much better in this regard than another brand I tried. I have injected in the upper thighs and abdominally. My lab work suggests that the leg injections are absorbed more slowly. Intuitively I might have thought the opposite would be true, but I recall someone posting research supporting the idea of relatively faster abdominal absorption. In any case, for my blend to work as intended it seems as though I must inject into the abdomen.