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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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<blockquote data-quote="madman" data-source="post: 205362" data-attributes="member: 13851"><p>Both are solvents and enhance the solubility/reduce the viscosity of the prodrug.</p><p></p><p>Mind you it would come down to the concentration used.</p><p></p><p>Most esterified injectable T preparations tend to use BOH as the main excipient.</p><p></p><p>Some use both although BOH tends to be a higher concentration.</p><p></p><p></p><p></p><p></p><p></p><p><strong>My reply from a previous thread:</strong></p><p></p><p>Regarding half-lives keep in mind that a majority of studies on the PK/PD of the various T-esters were done using <u>IM (once weekly/fortnightly) injections</u> in a small number of subjects and most of the literature is from decades ago.</p><p></p><p>There are many other factors that affect the rate at which the testosterone is released from the oily depot at the injection site.</p><p></p><p>Sub-q vs IM, the volume of injection, injection depth, site of injection, lymphatic flow,<strong><em> the concentration of BOH (benzyl alcohol) are other possible factors that can affect absorption rates of the esterified hormone.</em></strong></p><p></p><p>I have stated in the past that BOH apparently causes a large bolus of the prodrug to be released earlier which was discussed in this paper (NEW INSIGHTS INTO DRUG ABSORPTION FROM OIL DEPOTS) that I posted in a thread from 2018</p><p></p><p><strong><em>*It is demonstrated in this dissertation that there is a role of the excipient BOH in yielding an initially high absorption.</em></strong></p><p></p><p>I know there are even nandrolone studies showing that the addition of BOH (benzyl alcohol) which is commonly used in many injectable preparations has been shown to cause two distinct peaks.....one early and another days later as the BOH apparently causes a large bolus of the prodrug to be released early.</p><p></p><p><strong>Benzyl alcohol (BOH) is a commonly used excipient in oil depots in concentrations ranging from 1.5-10% v/v and is used as a</strong></p><p></p><p><em><strong>*solubility enhancer</strong></em></p><p><em><strong>*oil viscosity reducer</strong></em></p><p><strong><em>*local anesthetic</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*The absorption of nandrolone is enhanced by the presence of benzyl alcohol. <u>This is most likely an effect of altered OIL VISCOSITY and partition coefficient between the oil and aqueous phase</u>. <u>The absorption rate constant of compounds is found to be related to the logP of the SOLUBILIZED PRODRUG</u>. <u>The absorption rate is however not only determined by the Physico-chemical properties of the formulation but also by the TISSUE PROPERTIES</u>. <u>Here, it is argued that LYMPHATIC FLOW must be considered as a relevant parameter</u>.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>NEW INSIGHTS INTO DRUG ABSORPTION FROM OIL DEPOTS</strong></p><p></p><p><em>Besides the oil component, an additional excipient in oil depots is <strong>benzyl alcohol (BOH) (see Table 1.1). <u>The main function in oil depots is that it enhances the solubility of the processed lipophilic prodrugs</u> (Table 1.3). <u>The second function of BOH is to ease the administration because of its viscosity-reducing effect</u>. </strong></em></p><p></p><p><strong><em><u>The last function of BOH is that it acts as a local anesthetic</u>.</em></strong><em> Other frequently used excipients are benzyl benzoate (BBA) and ethanol (EtOH). An overview is given in Table 1.3 below</em></p><p></p><p><strong>Table 1.3: An overview of other frequently used excipients in oil depots</strong></p><p><em>[ATTACH=full]15757[/ATTACH]</em></p></blockquote><p></p>
[QUOTE="madman, post: 205362, member: 13851"] Both are solvents and enhance the solubility/reduce the viscosity of the prodrug. Mind you it would come down to the concentration used. Most esterified injectable T preparations tend to use BOH as the main excipient. Some use both although BOH tends to be a higher concentration. [B]My reply from a previous thread:[/B] Regarding half-lives keep in mind that a majority of studies on the PK/PD of the various T-esters were done using [U]IM (once weekly/fortnightly) injections[/U] in a small number of subjects and most of the literature is from decades ago. There are many other factors that affect the rate at which the testosterone is released from the oily depot at the injection site. Sub-q vs IM, the volume of injection, injection depth, site of injection, lymphatic flow,[B][I] the concentration of BOH (benzyl alcohol) are other possible factors that can affect absorption rates of the esterified hormone.[/I][/B] I have stated in the past that BOH apparently causes a large bolus of the prodrug to be released earlier which was discussed in this paper (NEW INSIGHTS INTO DRUG ABSORPTION FROM OIL DEPOTS) that I posted in a thread from 2018 [B][I]*It is demonstrated in this dissertation that there is a role of the excipient BOH in yielding an initially high absorption.[/I][/B] I know there are even nandrolone studies showing that the addition of BOH (benzyl alcohol) which is commonly used in many injectable preparations has been shown to cause two distinct peaks.....one early and another days later as the BOH apparently causes a large bolus of the prodrug to be released early. [B]Benzyl alcohol (BOH) is a commonly used excipient in oil depots in concentrations ranging from 1.5-10% v/v and is used as a[/B] [I][B]*solubility enhancer *oil viscosity reducer[/B][/I] [B][I]*local anesthetic *The absorption of nandrolone is enhanced by the presence of benzyl alcohol. [U]This is most likely an effect of altered OIL VISCOSITY and partition coefficient between the oil and aqueous phase[/U]. [U]The absorption rate constant of compounds is found to be related to the logP of the SOLUBILIZED PRODRUG[/U]. [U]The absorption rate is however not only determined by the Physico-chemical properties of the formulation but also by the TISSUE PROPERTIES[/U]. [U]Here, it is argued that LYMPHATIC FLOW must be considered as a relevant parameter[/U].[/I] NEW INSIGHTS INTO DRUG ABSORPTION FROM OIL DEPOTS[/B] [I]Besides the oil component, an additional excipient in oil depots is [B]benzyl alcohol (BOH) (see Table 1.1). [U]The main function in oil depots is that it enhances the solubility of the processed lipophilic prodrugs[/U] (Table 1.3). [U]The second function of BOH is to ease the administration because of its viscosity-reducing effect[/U]. [/B][/I] [B][I][U]The last function of BOH is that it acts as a local anesthetic[/U].[/I][/B][I] Other frequently used excipients are benzyl benzoate (BBA) and ethanol (EtOH). An overview is given in Table 1.3 below[/I] [B]Table 1.3: An overview of other frequently used excipients in oil depots[/B] [I][ATTACH type="full" alt="1627152172646.png"]15757[/ATTACH][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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