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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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<blockquote data-quote="madman" data-source="post: 205333" data-attributes="member: 13851"><p>Need to keep in mind whether one is injecting cyp/enanthate/prop that post-injection there will be an initial burst release of T and levels will start rising within the first 2 hrs.</p><p></p><p>T levels will spike up fairly quickly even when using the medium-chain esters.</p><p></p><p>Enanthate has been shown to reach Tmax 10 hrs.</p><p></p><p>Even then when injecting prop T levels will not peak as fast as <strong><em>unesterified </em></strong>T suspension let alone Natesto!</p><p></p><p>See no point in injecting prop twice daily.</p><p></p><p></p><p></p><p></p><p><strong>15.6.1 Testosterone propionate</strong></p><p></p><p><em>Single-dose pharmacokinetics of 50 mg testosterone propionate after IM injection to seven hypogonadal patients, and the best-fit pharmacokinetic profile, are shown in Fig. 15.4 (Nieschlag et al. 1976). <strong><em>Maximal testosterone levels in the supraphysiological range were seen shortly after injection (40.2 nmol/l, <u>Tmax = 14 h</u>).</em></strong> Testosterone levels below the normal range were observed following day two (57 h) after injection. The calculated values were 1843 nmol·h/l for the area under the curve (AUC); 1.5 d for mean residence time (MRT); and <strong><em>0.8 d for terminal half-life</em></strong> (Table 15.2).</em></p><p></p><p>Based on single-dose pharmacokinetic parameters, a multiple-dose pharmacokinetic simulation was performed. Expected testosterone serum concentrations after multiple dosing of 50 mg testosterone propionate, twice per week (e.g. injections Mondays and Thursdays, 8 a.m.), are shown in Fig. 15.5. <strong><em>Shortly after injection, <u>high supraphysiological testosterone serum concentrations of up to 45 nmol/l are observed</u>. At the end of the injection interval (<u>three and four days, respectively</u>), testosterone serum concentrations below the lower range of normal testosterone values are projected (7 nmol/l and 3 nmol/l, respectively).</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>15.6.4 Testosterone ester combinations</strong></p><p></p><p><em>Testosterone ester mixtures have been widely used for substitution therapy of male hypogonadism (e.g. Testoviron® Depot 50: 20 mg testosterone propionate and 55 mg testosterone enanthate; Testoviron® Depot 100: 25 mg testosterone propionate and 110 mg testosterone enanthate; Sustanon® 250: 30 mg testosterone propionate, 60 mg testosterone phenylpropionate, 60 mg testosterone isocaproate, and 100 mg testosterone decanoate). </em><strong><em>These combinations are used following the postulate that the so-called short-acting testosterone ester (e.g. <u>testosterone propionate</u>) is the effective testosterone for substitution during the <u>first days of treatment</u>, and the so-called long-acting testosterone (e.g. <u>testosterone enanthate</u>) warrants effective substitution for the <u>end of the injection interval</u>. <u>However, this assumption is not supported by the pharmacokinetic parameters of the individual testosterone esters</u>. BOTH TESTOSTERONE PROPIONATE AND TESTOSTERONE ENANTHATE CAUSE THE HIGHEST TESTOSTERONE SERUM CONCENTRATIONS SHORTLY AFTER INJECTION (Fig. 15.4 and Fig. 15.6). <u>Accordingly, the addition of testosterone propionate to testosterone enanthate only increases the</u> INITIAL UNDESIRED TESTOSTERONE PEAK <u>and worsens the pharmacokinetic profile that ideally should follow zero-order kinetics </u>(Fig. 15.9). </em></strong><em>The computer simulation agrees well with the limited published single-dose testosterone values that have been measured in hypogonadal patients treated with the combination of testosterone propionate and testosterone enanthate. Maximal increases of approximately 40 nmol/l testosterone over basal values are described one day after IM administration of a testosterone ester combination</em></p></blockquote><p></p>
[QUOTE="madman, post: 205333, member: 13851"] Need to keep in mind whether one is injecting cyp/enanthate/prop that post-injection there will be an initial burst release of T and levels will start rising within the first 2 hrs. T levels will spike up fairly quickly even when using the medium-chain esters. Enanthate has been shown to reach Tmax 10 hrs. Even then when injecting prop T levels will not peak as fast as [B][I]unesterified [/I][/B]T suspension let alone Natesto! See no point in injecting prop twice daily. [B]15.6.1 Testosterone propionate[/B] [I]Single-dose pharmacokinetics of 50 mg testosterone propionate after IM injection to seven hypogonadal patients, and the best-fit pharmacokinetic profile, are shown in Fig. 15.4 (Nieschlag et al. 1976). [B][I]Maximal testosterone levels in the supraphysiological range were seen shortly after injection (40.2 nmol/l, [U]Tmax = 14 h[/U]).[/I][/B] Testosterone levels below the normal range were observed following day two (57 h) after injection. The calculated values were 1843 nmol·h/l for the area under the curve (AUC); 1.5 d for mean residence time (MRT); and [B][I]0.8 d for terminal half-life[/I][/B] (Table 15.2).[/I] Based on single-dose pharmacokinetic parameters, a multiple-dose pharmacokinetic simulation was performed. Expected testosterone serum concentrations after multiple dosing of 50 mg testosterone propionate, twice per week (e.g. injections Mondays and Thursdays, 8 a.m.), are shown in Fig. 15.5. [B][I]Shortly after injection, [U]high supraphysiological testosterone serum concentrations of up to 45 nmol/l are observed[/U]. At the end of the injection interval ([U]three and four days, respectively[/U]), testosterone serum concentrations below the lower range of normal testosterone values are projected (7 nmol/l and 3 nmol/l, respectively).[/I] 15.6.4 Testosterone ester combinations[/B] [I]Testosterone ester mixtures have been widely used for substitution therapy of male hypogonadism (e.g. Testoviron® Depot 50: 20 mg testosterone propionate and 55 mg testosterone enanthate; Testoviron® Depot 100: 25 mg testosterone propionate and 110 mg testosterone enanthate; Sustanon® 250: 30 mg testosterone propionate, 60 mg testosterone phenylpropionate, 60 mg testosterone isocaproate, and 100 mg testosterone decanoate). [/I][B][I]These combinations are used following the postulate that the so-called short-acting testosterone ester (e.g. [U]testosterone propionate[/U]) is the effective testosterone for substitution during the [U]first days of treatment[/U], and the so-called long-acting testosterone (e.g. [U]testosterone enanthate[/U]) warrants effective substitution for the [U]end of the injection interval[/U]. [U]However, this assumption is not supported by the pharmacokinetic parameters of the individual testosterone esters[/U]. BOTH TESTOSTERONE PROPIONATE AND TESTOSTERONE ENANTHATE CAUSE THE HIGHEST TESTOSTERONE SERUM CONCENTRATIONS SHORTLY AFTER INJECTION (Fig. 15.4 and Fig. 15.6). [U]Accordingly, the addition of testosterone propionate to testosterone enanthate only increases the[/U] INITIAL UNDESIRED TESTOSTERONE PEAK [U]and worsens the pharmacokinetic profile that ideally should follow zero-order kinetics [/U](Fig. 15.9). [/I][/B][I]The computer simulation agrees well with the limited published single-dose testosterone values that have been measured in hypogonadal patients treated with the combination of testosterone propionate and testosterone enanthate. Maximal increases of approximately 40 nmol/l testosterone over basal values are described one day after IM administration of a testosterone ester combination[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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