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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Thinking of stopping my AI. Thoughts.
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<blockquote data-quote="Blackhawk" data-source="post: 148404" data-attributes="member: 16042"><p>Uh... I'd like to point out that the use of the word "toxicity" in that article is entirely bogus.</p><p></p><p></p><p>"Toxicity" in every case in that article is used as a blatantly wrong substitute word for correct terminology like "side effect", "sign", "symptom" and "adverse effect". It is not even synonymous.</p><p></p><p>A few examples, the article calls osteoporosis, myalgias and arthralgias "toxicities".</p><p></p><p>Osteoporosis is not a toxicity, it is a diagnosable condition and also could be referred to as a sign relative to it's associated cause e.g. osteoporosis is a potential sign of having low estrogen. Another unrelated example: A heart attack is a potential sign of coronary artery disease... Osteoporosis is no more a "toxicity" than a heart attack is a "toxicity"</p><p></p><p>Likewise, myalgias and arthralgias are aches and pains, they are symptoms. They are not "toxicities".</p><p></p><p>And in the next paragraph, It even puts "fracture" in the category of "toxicity... Sorry, WHAT? A fracture is not a toxicity either. It is a friggin broken bone.</p><p></p><p>I am not saying there is no possibility that arimidex has toxicity, I am saying is that the article shows no documentation or evidence whatsoever of toxicity as a cause, and the author's use of the term is blatantly wrong. So people are now citing this as evidence of toxicity of anastrozole? Incredible. It is evidence of potential <strong>side effects</strong> of anastrozole, yes, however:</p><p></p><p>Every instance of the term "toxicity" refers to a sign, symptom or condition of LOW ESTROGEN!</p><p></p><p>So from the article and the study itself:</p><p></p><p>"The study was based on a retrospective chart review of 640 postmenopausal women with early-stage hormone-sensitive breast cancer"</p><p></p><p>"The women received an AI either as upfront therapy for five years (43%), as part of a switching strategy after two to three years of tamoxifen (36%), or as extended therapy after five years of tamoxifen (21%)"</p><p></p><p>OK then:</p><p></p><p>Arimidex standard label use is for hormone receptor positive and advanced and metastatic breast cancers in post menopausal women intended to suppress estrogen to below 7. The dose is 1mg/day.</p><p></p><p>Indeed, if you suppress your E2 below 7 for 5 years you will very likely develop Osteoporosis, myalgias and arthralgias (and among other things increase your risk of cardiovascular disease and likelihood of all cause mortality) due to estrogen suppression.</p><p></p><p>Did any of the patients in the studies the article refers to have healthful E2 levels? I suspect not if the treatment target is that low and the dose is that high for that long.</p><p></p><p>The article notes some side effects of estrogen suppressed to unhealthful levels... No doubt, Yes.</p><p></p><p>Also, ALL of these women had BREAST CANCER and were most likely taking additional meds. Anastrozole's use for breast cancer is typically as an "adjuvant" or additional treatment to enhance other primary treatments. ... would breast cancer itself and other cancer drugs used in conjunction with Arimidex not also cause some of these signs and symptoms as well?</p><p></p><p>Bottom line, the article is seriously flawed at many levels and in no way whatsoever determines toxicity as causation.</p><p></p><p>So once again, where is any evidence Arimidex is toxic in a harmful way if you use it responsibly and do not suppress E2 to unhealthful levels? If the stuff is indeed toxic, I want to know, and I want to see that documentation please.</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 148404, member: 16042"] Uh... I'd like to point out that the use of the word "toxicity" in that article is entirely bogus. "Toxicity" in every case in that article is used as a blatantly wrong substitute word for correct terminology like "side effect", "sign", "symptom" and "adverse effect". It is not even synonymous. A few examples, the article calls osteoporosis, myalgias and arthralgias "toxicities". Osteoporosis is not a toxicity, it is a diagnosable condition and also could be referred to as a sign relative to it's associated cause e.g. osteoporosis is a potential sign of having low estrogen. Another unrelated example: A heart attack is a potential sign of coronary artery disease... Osteoporosis is no more a "toxicity" than a heart attack is a "toxicity" Likewise, myalgias and arthralgias are aches and pains, they are symptoms. They are not "toxicities". And in the next paragraph, It even puts "fracture" in the category of "toxicity... Sorry, WHAT? A fracture is not a toxicity either. It is a friggin broken bone. I am not saying there is no possibility that arimidex has toxicity, I am saying is that the article shows no documentation or evidence whatsoever of toxicity as a cause, and the author's use of the term is blatantly wrong. So people are now citing this as evidence of toxicity of anastrozole? Incredible. It is evidence of potential [B]side effects[/B] of anastrozole, yes, however: Every instance of the term "toxicity" refers to a sign, symptom or condition of LOW ESTROGEN! So from the article and the study itself: "The study was based on a retrospective chart review of 640 postmenopausal women with early-stage hormone-sensitive breast cancer" "The women received an AI either as upfront therapy for five years (43%), as part of a switching strategy after two to three years of tamoxifen (36%), or as extended therapy after five years of tamoxifen (21%)" OK then: Arimidex standard label use is for hormone receptor positive and advanced and metastatic breast cancers in post menopausal women intended to suppress estrogen to below 7. The dose is 1mg/day. Indeed, if you suppress your E2 below 7 for 5 years you will very likely develop Osteoporosis, myalgias and arthralgias (and among other things increase your risk of cardiovascular disease and likelihood of all cause mortality) due to estrogen suppression. Did any of the patients in the studies the article refers to have healthful E2 levels? I suspect not if the treatment target is that low and the dose is that high for that long. The article notes some side effects of estrogen suppressed to unhealthful levels... No doubt, Yes. Also, ALL of these women had BREAST CANCER and were most likely taking additional meds. Anastrozole's use for breast cancer is typically as an "adjuvant" or additional treatment to enhance other primary treatments. ... would breast cancer itself and other cancer drugs used in conjunction with Arimidex not also cause some of these signs and symptoms as well? Bottom line, the article is seriously flawed at many levels and in no way whatsoever determines toxicity as causation. So once again, where is any evidence Arimidex is toxic in a harmful way if you use it responsibly and do not suppress E2 to unhealthful levels? If the stuff is indeed toxic, I want to know, and I want to see that documentation please. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Thinking of stopping my AI. Thoughts.
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