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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Thinking about starting trt
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<blockquote data-quote="madman" data-source="post: 207261" data-attributes="member: 13851"><p>I would say it is still going over your head.</p><p></p><p>Whether one is starting trt or tweaking a protocol (increasing dose) anyone who has an understanding of how esterified exogenous T works should very well know that it is very common for one to experience what we call a honeymoon period during the weeks leading up until blood levels have stabilized as dopamine/androgen levels are increasing (AR receptors lighting up) and many tend to experience an almost euphoric like feeling let alone strong increases in libido/erections and overall well-being.....unfortunately this is temporary and short-lived as the body will eventually adapt and things tend to level off.....gauging how you truly feel during this transition is a grave mistake.</p><p></p><p>Even when tweaking a protocol (decreasing dose) it is very common for one to experience ups/downs let alone be in for a bumpy ride during the weeks leading up until blood levels have stabilized (4-6 weeks) only to end up feeling much better 2-3 months in on such protocol.</p><p></p><p>Once blood levels have stabilized (4-6 weeks) and the new set point is reached the next couple of months is where the rubber meets the road.</p><p></p><p>This is when one should truly gauge how they feel overall regarding relief/improvement of low-T symptoms let alone claiming whether such protocol is a success or failure.</p><p></p><p>Unfortunately, everyone is in for that quick fix!</p><p></p><p>Top it all off that many take drastic measures when tweaking a protocol (increasing/decreasing dose too much) of the hop and again it is common for many to experience ups/downs during the following weeks leading up until blood levels have stabilized (4-6 weeks) </p><p></p><p>The new protocol needs to be given a fighting chance as we need to allow the body time to fully adapt to the new set point which was reached once blood levels have stabilized (first 4-6 weeks).</p><p></p><p>Do not even get me started on the ones that are jacked up on T from the get-go (200 mg T/week) that has them feeling stellar for the first 6 weeks only to be let down 2-3 months in because trough FT levels are way too high leaving them feeling horrible.</p><p></p><p>If they had any sense in their heads let alone understood how esterified exogenous T works then they would be prepared for the fact 12 weeks is needed to truly gauge the effectiveness of a protocol and whether it was a success or failure.</p><p></p><p>The body will eventually adapt to the new setpoint and this will become the new norm.</p><p></p><p>Every time you decide to switch things up (increase/decrease dose T) the body will need time to fully adapt once the new setpoint is reached.</p><p></p><p>Although effects on quality of life become evident within 3–6 weeks the maximum benefits take longer.</p><p></p><p></p><p></p><p></p><p><strong><em>I’ve been tested countless times with all the labs you yourself are recommending for years since I started all this with a doctor well versed in it and everything you’d read around here and the general philosophies of this community. That’s where my peak TT and FT sit. Since trying T3 over the holidays my SHBG went down to 25 and screwed everything up for me something fierce, but before that it’d been around 35-40, depending on injection frequency. I inject daily in the morning, including when I get tested. Those are about as close to my peaks as you’re going to get. Outside of a GP or something I’m not sure anybody actually uses tests that aren’t the ones you prefer. Nelson and everybody else pretty much laid everything out for everyone and they all kind of do the same thing now based on the good work you guys have done over the years, which is commendable.</em></strong></p><p></p><p>Although I recommend testing FT using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best) whether through Labcorp or Quest Diagnostics I have seen some wacky results from Quest Diagnostics let alone the reference ranges used.</p><p></p><p>If anything I would prefer testing FT through Labcorp using ED or UF as many of the results I have seen on here seem to be more consistent especially in cases of higher SHBG.</p><p></p><p></p><p>1. <a href="https://www.labcorp.com/tests/500726/testosterone-free-mass-spectrometry-equilibrium-dialysis-endocrine-sciences" target="_blank">500726: Testosterone, Free, Mass Spectrometry/Equilibrium Dialysis (Endocrine Sciences) | Labcorp</a> (reference range 52-280 pg/mL)</p><p></p><p>2. <a href="https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms" target="_blank">070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp</a> (reference range 5.00 -21.00 ng/dL)</p><p></p><p></p><p>Not sure whether you are using Quest or Labcorp?</p><p></p><p>Post full set of labs.</p><p></p><p>Again can easily hit a high-end let alone absurdly high FT with a TT 1000-1300 ng/dL even men with high/highish SHBG.</p><p></p><p>Dr. Nutsack uses/relies upon this one.....</p><p><a href="https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms" target="_blank">070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp</a> (reference range 5.00 -21.00 ng/dL)</p><p></p><p></p><p></p><p></p><p><em><strong>Jay Campbell wrote a book on TRT that’s pretty popular and in general has had a large impact on people doing TRT and related things. He’s all over the place in what he recommends and pretty much is telling people to run cycles responsibly. His guests tend to be good, but I do not personally trust everything he says myself because of how all over the place it is and how sometimes it’s verifiably wrong. I’m sure he probably means well, and plenty of what he says matches what you’d hear around here. He’s one of the guys that popularized terms like shooting for what’s ‘optimal’ and things like that.</strong></em></p><p></p><p>I was kidding when I stated Jay who?</p><p></p><p>Have no interest in him let alone some of the folks he rolls with!</p></blockquote><p></p>
[QUOTE="madman, post: 207261, member: 13851"] I would say it is still going over your head. Whether one is starting trt or tweaking a protocol (increasing dose) anyone who has an understanding of how esterified exogenous T works should very well know that it is very common for one to experience what we call a honeymoon period during the weeks leading up until blood levels have stabilized as dopamine/androgen levels are increasing (AR receptors lighting up) and many tend to experience an almost euphoric like feeling let alone strong increases in libido/erections and overall well-being.....unfortunately this is temporary and short-lived as the body will eventually adapt and things tend to level off.....gauging how you truly feel during this transition is a grave mistake. Even when tweaking a protocol (decreasing dose) it is very common for one to experience ups/downs let alone be in for a bumpy ride during the weeks leading up until blood levels have stabilized (4-6 weeks) only to end up feeling much better 2-3 months in on such protocol. Once blood levels have stabilized (4-6 weeks) and the new set point is reached the next couple of months is where the rubber meets the road. This is when one should truly gauge how they feel overall regarding relief/improvement of low-T symptoms let alone claiming whether such protocol is a success or failure. Unfortunately, everyone is in for that quick fix! Top it all off that many take drastic measures when tweaking a protocol (increasing/decreasing dose too much) of the hop and again it is common for many to experience ups/downs during the following weeks leading up until blood levels have stabilized (4-6 weeks) The new protocol needs to be given a fighting chance as we need to allow the body time to fully adapt to the new set point which was reached once blood levels have stabilized (first 4-6 weeks). Do not even get me started on the ones that are jacked up on T from the get-go (200 mg T/week) that has them feeling stellar for the first 6 weeks only to be let down 2-3 months in because trough FT levels are way too high leaving them feeling horrible. If they had any sense in their heads let alone understood how esterified exogenous T works then they would be prepared for the fact 12 weeks is needed to truly gauge the effectiveness of a protocol and whether it was a success or failure. The body will eventually adapt to the new setpoint and this will become the new norm. Every time you decide to switch things up (increase/decrease dose T) the body will need time to fully adapt once the new setpoint is reached. Although effects on quality of life become evident within 3–6 weeks the maximum benefits take longer. [B][I]I’ve been tested countless times with all the labs you yourself are recommending for years since I started all this with a doctor well versed in it and everything you’d read around here and the general philosophies of this community. That’s where my peak TT and FT sit. Since trying T3 over the holidays my SHBG went down to 25 and screwed everything up for me something fierce, but before that it’d been around 35-40, depending on injection frequency. I inject daily in the morning, including when I get tested. Those are about as close to my peaks as you’re going to get. Outside of a GP or something I’m not sure anybody actually uses tests that aren’t the ones you prefer. Nelson and everybody else pretty much laid everything out for everyone and they all kind of do the same thing now based on the good work you guys have done over the years, which is commendable.[/I][/B] Although I recommend testing FT using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best) whether through Labcorp or Quest Diagnostics I have seen some wacky results from Quest Diagnostics let alone the reference ranges used. If anything I would prefer testing FT through Labcorp using ED or UF as many of the results I have seen on here seem to be more consistent especially in cases of higher SHBG. 1. [URL='https://www.labcorp.com/tests/500726/testosterone-free-mass-spectrometry-equilibrium-dialysis-endocrine-sciences']500726: Testosterone, Free, Mass Spectrometry/Equilibrium Dialysis (Endocrine Sciences) | Labcorp[/URL] (reference range 52-280 pg/mL) 2. [URL='https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms']070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp[/URL] (reference range 5.00 -21.00 ng/dL) Not sure whether you are using Quest or Labcorp? Post full set of labs. Again can easily hit a high-end let alone absurdly high FT with a TT 1000-1300 ng/dL even men with high/highish SHBG. Dr. Nutsack uses/relies upon this one..... [URL='https://www.labcorp.com/tests/070038/testosterone-free-equilibrium-ultrafiltration-with-total-testosterone-lc-ms-ms']070038: Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS-MS | Labcorp[/URL] (reference range 5.00 -21.00 ng/dL) [I][B]Jay Campbell wrote a book on TRT that’s pretty popular and in general has had a large impact on people doing TRT and related things. He’s all over the place in what he recommends and pretty much is telling people to run cycles responsibly. His guests tend to be good, but I do not personally trust everything he says myself because of how all over the place it is and how sometimes it’s verifiably wrong. I’m sure he probably means well, and plenty of what he says matches what you’d hear around here. He’s one of the guys that popularized terms like shooting for what’s ‘optimal’ and things like that.[/B][/I] I was kidding when I stated Jay who? Have no interest in him let alone some of the folks he rolls with! [/QUOTE]
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Thinking about starting trt
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