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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Things went sideways after lowering dose/adding AI
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<blockquote data-quote="madman" data-source="post: 147720" data-attributes="member: 13851"><p><span style="font-size: 15px"><span style="color: rgb(51, 51, 51)">You stated "<strong>So,</strong></span><span style="color: rgb(184, 49, 47)"><strong> after 8 weeks in</strong></span><span style="color: rgb(51, 51, 51)"><strong>, I was </strong></span><span style="color: rgb(184, 49, 47)"><strong>feeling great</strong></span><span style="color: rgb(51, 51, 51)"><strong> with maybe </strong></span><span style="color: rgb(184, 49, 47)"><strong>a little bit </strong></span><span style="color: rgb(51, 51, 51)"><strong>of </strong></span><span style="color: rgb(184, 49, 47)"><strong>water retention</strong></span><span style="color: rgb(51, 51, 51)"><strong>."</strong></span></span></p><p></p><p></p><p>First off you tested your FT with the wrong assay!</p><p></p><p>Unfortunately regarding testing ones FT <strong>(</strong><span style="color: rgb(0, 0, 0)"><strong>free testosterone</strong></span><strong>) </strong>most are using the <strong><span style="color: rgb(184, 49, 47)">direct analog-based free testosterone immunoassays</span></strong> which are <strong><span style="color: rgb(184, 49, 47)">inaccurate</span></strong><span style="color: rgb(184, 49, 47)">.</span></p><p></p><p>If anything you should be getting the <strong><span style="color: rgb(184, 49, 47)">equilibrium dialysis</span></strong> or better yet save yourself the money and use the<strong> Calculate free testosterone with <span style="color: rgb(184, 49, 47)">TruT </span>by <span style="color: rgb(184, 49, 47)">FPT</span> - </strong><a href="https://tru-t.org/" target="_blank">Try the public free testosterone calculator at tru-t.org</a></p><p></p><p>Do you truly know your FT levels?</p><p></p><p>What were you expecting.....reason your e2 is so high is simply because your FT levels are too high for you on such protocol 160 mg/week (80 mg every 3.5 days).</p><p></p><p>Your TT is 1350 ng/dL (trough) and having SHBG at 37.1 nmol/L would have your <span style="color: rgb(184, 49, 47)"><strong>FT </strong></span>levels at <strong><span style="color: rgb(184, 49, 47)">48.80 ng/dL </span>(range <span style="color: rgb(184, 49, 47)">16-31 </span>ng/dL)</strong></p><p></p><p></p><p>[ATTACH=full]7407[/ATTACH]</p><p></p><p></p><p></p><p>You than state.....<strong>"</strong><span style="font-size: 15px"><span style="color: rgb(51, 51, 51)"><strong>After reviewing with defy, we agreed to </strong></span><span style="color: rgb(184, 49, 47)"><strong>lower me from 160mg/week (two 80 week) to 140mg (two 70mg)</strong></span><span style="color: rgb(51, 51, 51)"><strong> and </strong></span><span style="color: rgb(184, 49, 47)"><strong>add 0.1mg adex per week. </strong></span><span style="color: rgb(51, 51, 51)"><strong>No HCG or anything else either course. Fast forward</strong></span><span style="color: rgb(184, 49, 47)"><strong> 3 weeks and I feel like shit</strong></span><span style="color: rgb(51, 51, 51)"><strong>. </strong></span><span style="color: rgb(184, 49, 47)"><strong>ED that I’ve never had, apathetic, lost muscle size, just not the same</strong></span><span style="color: rgb(51, 51, 51)"><strong>. Pulled quick labs and unfortunately they ran the wrong E2 test but here goes"</strong></span></span></p><p></p><p></p><p>If anything lowering dose slightly without adding an a.i. would have been the more sensible approach as you easily had room to lower your TT/FT levels which would result</p><p>in lower e2.</p><p></p><p>Now on the new protocol 140 mg/week (70 mg every 3.5 days) your TT is 883 ng/dL and your SHBG is 26.8 nmol/L which has your <span style="color: rgb(184, 49, 47)"><strong>FT</strong></span> level at <strong><span style="color: rgb(184, 49, 47)">31.90 ng/dL </span></strong>(just slightly above top end reference <strong>range <span style="color: rgb(184, 49, 47)">16-31 </span>ng/dL</strong>)</p><p></p><p>Your FT levels are still very good.</p><p></p><p>I would say the main reasons you feel like shit are because of the addition of the a.i. which resulted in hammering your e2 too low although we have no idea where it truly sat as the wrong testing method was used.</p><p></p><p>Top it all off 2 changes were made at once.....lowering your dose by 20 mg/week and adding an aromatase inhibitor.</p><p></p><p>Also anytime one tweaks a protocol whether increasing/decreasing T dose hormones will be in flux during the following weeks until levels stabilize (6 weeks) so it is common for one to experience ups/downs regarding mood/energy/libido/erections so to judge how you feel during this transition when hormones are in flux is pointless and even than once T levels have stabilized I would give it 2-3 months at new said dose/protocol to truly gauge whether it is beneficial or not.</p><p></p><p>[ATTACH=full]7408[/ATTACH]</p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">* </span>Highly doubtful you lost muscle size!</strong></p></blockquote><p></p>
[QUOTE="madman, post: 147720, member: 13851"] [SIZE=15px][COLOR=rgb(51, 51, 51)]You stated "[B]So,[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] after 8 weeks in[/B][/COLOR][COLOR=rgb(51, 51, 51)][B], I was [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]feeling great[/B][/COLOR][COLOR=rgb(51, 51, 51)][B] with maybe [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]a little bit [/B][/COLOR][COLOR=rgb(51, 51, 51)][B]of [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]water retention[/B][/COLOR][COLOR=rgb(51, 51, 51)][B]."[/B][/COLOR][/SIZE] First off you tested your FT with the wrong assay! Unfortunately regarding testing ones FT [B]([/B][COLOR=rgb(0, 0, 0)][B]free testosterone[/B][/COLOR][B]) [/B]most are using the [B][COLOR=rgb(184, 49, 47)]direct analog-based free testosterone immunoassays[/COLOR][/B] which are [B][COLOR=rgb(184, 49, 47)]inaccurate[/COLOR][/B][COLOR=rgb(184, 49, 47)].[/COLOR] If anything you should be getting the [B][COLOR=rgb(184, 49, 47)]equilibrium dialysis[/COLOR][/B] or better yet save yourself the money and use the[B] Calculate free testosterone with [COLOR=rgb(184, 49, 47)]TruT [/COLOR]by [COLOR=rgb(184, 49, 47)]FPT[/COLOR] - [/B][URL='https://tru-t.org/']Try the public free testosterone calculator at tru-t.org[/URL] Do you truly know your FT levels? What were you expecting.....reason your e2 is so high is simply because your FT levels are too high for you on such protocol 160 mg/week (80 mg every 3.5 days). Your TT is 1350 ng/dL (trough) and having SHBG at 37.1 nmol/L would have your [COLOR=rgb(184, 49, 47)][B]FT [/B][/COLOR]levels at [B][COLOR=rgb(184, 49, 47)]48.80 ng/dL [/COLOR](range [COLOR=rgb(184, 49, 47)]16-31 [/COLOR]ng/dL)[/B] [ATTACH=full]7407[/ATTACH] You than state.....[B]"[/B][SIZE=15px][COLOR=rgb(51, 51, 51)][B]After reviewing with defy, we agreed to [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]lower me from 160mg/week (two 80 week) to 140mg (two 70mg)[/B][/COLOR][COLOR=rgb(51, 51, 51)][B] and [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]add 0.1mg adex per week. [/B][/COLOR][COLOR=rgb(51, 51, 51)][B]No HCG or anything else either course. Fast forward[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] 3 weeks and I feel like shit[/B][/COLOR][COLOR=rgb(51, 51, 51)][B]. [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]ED that I’ve never had, apathetic, lost muscle size, just not the same[/B][/COLOR][COLOR=rgb(51, 51, 51)][B]. Pulled quick labs and unfortunately they ran the wrong E2 test but here goes"[/B][/COLOR][/SIZE] If anything lowering dose slightly without adding an a.i. would have been the more sensible approach as you easily had room to lower your TT/FT levels which would result in lower e2. Now on the new protocol 140 mg/week (70 mg every 3.5 days) your TT is 883 ng/dL and your SHBG is 26.8 nmol/L which has your [COLOR=rgb(184, 49, 47)][B]FT[/B][/COLOR] level at [B][COLOR=rgb(184, 49, 47)]31.90 ng/dL [/COLOR][/B](just slightly above top end reference [B]range [COLOR=rgb(184, 49, 47)]16-31 [/COLOR]ng/dL[/B]) Your FT levels are still very good. I would say the main reasons you feel like shit are because of the addition of the a.i. which resulted in hammering your e2 too low although we have no idea where it truly sat as the wrong testing method was used. Top it all off 2 changes were made at once.....lowering your dose by 20 mg/week and adding an aromatase inhibitor. Also anytime one tweaks a protocol whether increasing/decreasing T dose hormones will be in flux during the following weeks until levels stabilize (6 weeks) so it is common for one to experience ups/downs regarding mood/energy/libido/erections so to judge how you feel during this transition when hormones are in flux is pointless and even than once T levels have stabilized I would give it 2-3 months at new said dose/protocol to truly gauge whether it is beneficial or not. [ATTACH=full]7408[/ATTACH] [B][COLOR=rgb(184, 49, 47)]* [/COLOR]Highly doubtful you lost muscle size![/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Things went sideways after lowering dose/adding AI
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