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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The "Your T3 is pooling" theory
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<blockquote data-quote="apsjiml" data-source="post: 167575" data-attributes="member: 12831"><p>pooling, or reverse t3 are two separate topics. </p><p></p><p>Pooling would be suggesting that the t3 is not getting into the cells and the free t3 levels is just "pooling in the blood" That is a stop the thyroid madness thing. I will say, Knowing people that went in for lab testing that have adrenal insufficiency as well as hypo thyroid I have seen them not take their cortisol on the day of the lab tests and their free t3 is way higher. The next time they go in for labs (usually to retest it) their free t3 is back down once they take their cortisol the morning of the lab test. I have seen that. . I have not seen studies on it. just mentioned in stop the thyroid madness. However, I have seen peoples labs like that. I will say I have seen many people go on t3 only and their free t3 went way down along with reverse t3, I think it is from " One potential problem with these methods is the separation of 3,5,3′-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3), due to the high level of structural similarity between the compounds. However, as rT3 is not physiologically active, it is necessary to be able to separate the two compounds in order to obtain an accurate result [<a href="https://link.springer.com/article/10.1007/s00216-019-01724-2#CR2" target="_blank">2</a>]. A study found that rT3 and T3 can be separated when the MS detector is operated in negative mode " I wonder sometimes how accurate the free t3 test is at times. because I never see lc-ms/ms used. </p><p></p><p></p><p>Now reverse t3 issues, the issue could obviously be if a person is taking t4, and they have high reverse t3 and low free t3, they can't keep taking a lot more t4, that is not going to work because it is just getting converted into reverse t3 instead of free t3. That is what reverse t3 is made from. (t4) Reverse t3 issues lack of deiodinase) are caused from anything from genetic issues, inflammation, low testosterone, low iron, low growth hormone and so many other things not yet known. When people have this issue, often times, they try to go up in thyroid because free t3 is not very good, and they go up in a combo thyroid therapy or t4 and all they end up with is high reverse t3 and still have lower free t3. As far as studies, they have one study on older people and compared people with a reverse t3 over the range and the others in the range and the people with the highest reverse t3, had a worse metabolism and health. Animal studies did show rt3 lowers their metabolism. More studies need to be done for sure. <a href="https://link.springer.com/article/10.1007/s00216-019-01724-2" target="_blank">A direct comparison of liquid chromatography-mass spectrometry with clinical routine testing immunoassay methods for the detection and quantification of thyroid hormones in blood serum</a> </p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113291/" target="_blank">How reliable are free thyroid and total T3 hormone assays?</a></p></blockquote><p></p>
[QUOTE="apsjiml, post: 167575, member: 12831"] pooling, or reverse t3 are two separate topics. Pooling would be suggesting that the t3 is not getting into the cells and the free t3 levels is just "pooling in the blood" That is a stop the thyroid madness thing. I will say, Knowing people that went in for lab testing that have adrenal insufficiency as well as hypo thyroid I have seen them not take their cortisol on the day of the lab tests and their free t3 is way higher. The next time they go in for labs (usually to retest it) their free t3 is back down once they take their cortisol the morning of the lab test. I have seen that. . I have not seen studies on it. just mentioned in stop the thyroid madness. However, I have seen peoples labs like that. I will say I have seen many people go on t3 only and their free t3 went way down along with reverse t3, I think it is from " One potential problem with these methods is the separation of 3,5,3′-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3), due to the high level of structural similarity between the compounds. However, as rT3 is not physiologically active, it is necessary to be able to separate the two compounds in order to obtain an accurate result [[URL='https://link.springer.com/article/10.1007/s00216-019-01724-2#CR2']2[/URL]]. A study found that rT3 and T3 can be separated when the MS detector is operated in negative mode " I wonder sometimes how accurate the free t3 test is at times. because I never see lc-ms/ms used. Now reverse t3 issues, the issue could obviously be if a person is taking t4, and they have high reverse t3 and low free t3, they can't keep taking a lot more t4, that is not going to work because it is just getting converted into reverse t3 instead of free t3. That is what reverse t3 is made from. (t4) Reverse t3 issues lack of deiodinase) are caused from anything from genetic issues, inflammation, low testosterone, low iron, low growth hormone and so many other things not yet known. When people have this issue, often times, they try to go up in thyroid because free t3 is not very good, and they go up in a combo thyroid therapy or t4 and all they end up with is high reverse t3 and still have lower free t3. As far as studies, they have one study on older people and compared people with a reverse t3 over the range and the others in the range and the people with the highest reverse t3, had a worse metabolism and health. Animal studies did show rt3 lowers their metabolism. More studies need to be done for sure. [URL="https://link.springer.com/article/10.1007/s00216-019-01724-2"]A direct comparison of liquid chromatography-mass spectrometry with clinical routine testing immunoassay methods for the detection and quantification of thyroid hormones in blood serum[/URL] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113291/"]How reliable are free thyroid and total T3 hormone assays?[/URL] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The "Your T3 is pooling" theory
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