ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The therapeutic effect of DHEA on vulvovaginal atrophy
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 196679" data-attributes="member: 13851"><p><strong>Fig. 3. Mechanisms of DHEA in treating VVA. DHEA is converted by vaginal mucosal cells into estrogen, including estradiol, and into androgens, including testosterone. In surrounding tissues, DHEAS is desulfurized and estrone can be formed through the activities of 3-β-steroid dehydrogenase (HSD), 17-β-HSD, and aromatase. Estrone can be combined with estrone sulfate (E1S) to form estrone reservoirs in the blood and tissues; And Estrone can be transformed through 17-β-HSD, which eventually leads to the local formation of free E2. The main pathway of estrogen metabolism is the formation of CYP1A1 and CYP1B1 catalyzed catechol estrogens (CEs) 2- and 4-hydroxy estrogens through hydroxylation, respectively. CEs may be further converted into more stable methoxy derivatives by catechol-O-methyltransferase (COMT). Abbreviations: DHEA: Dehydroepiandrosterone; DHEA-S: DHEA–sulfate; E1: estrone; E1S: estrone sulfate; A-dione: 5-androstene-3β, 17βdiol; E2: estradiol; ER: estrogen-receptor; ERE: estrogen-receptor element; E2S: estradiol sulfate; COMT: catechol-O-methyltransferase; CYP19A1: aromatase; 3β-HSD: 3β-hydroxysteroid dehydrogenase; AR: androgen receptors; ARE: androgen-response element.</strong></p><p>[ATTACH=full]13081[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 196679, member: 13851"] [B]Fig. 3. Mechanisms of DHEA in treating VVA. DHEA is converted by vaginal mucosal cells into estrogen, including estradiol, and into androgens, including testosterone. In surrounding tissues, DHEAS is desulfurized and estrone can be formed through the activities of 3-β-steroid dehydrogenase (HSD), 17-β-HSD, and aromatase. Estrone can be combined with estrone sulfate (E1S) to form estrone reservoirs in the blood and tissues; And Estrone can be transformed through 17-β-HSD, which eventually leads to the local formation of free E2. The main pathway of estrogen metabolism is the formation of CYP1A1 and CYP1B1 catalyzed catechol estrogens (CEs) 2- and 4-hydroxy estrogens through hydroxylation, respectively. CEs may be further converted into more stable methoxy derivatives by catechol-O-methyltransferase (COMT). Abbreviations: DHEA: Dehydroepiandrosterone; DHEA-S: DHEA–sulfate; E1: estrone; E1S: estrone sulfate; A-dione: 5-androstene-3β, 17βdiol; E2: estradiol; ER: estrogen-receptor; ERE: estrogen-receptor element; E2S: estradiol sulfate; COMT: catechol-O-methyltransferase; CYP19A1: aromatase; 3β-HSD: 3β-hydroxysteroid dehydrogenase; AR: androgen receptors; ARE: androgen-response element.[/B] [ATTACH type="full"]13081[/ATTACH] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The therapeutic effect of DHEA on vulvovaginal atrophy
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top