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<blockquote data-quote="FunkOdyssey" data-source="post: 267117" data-attributes="member: 44064"><p>So there are multiple things that affect SHBG level, and free T is just one of them. Conversely, SHBG is NOT one of the things that regulates the level of free T. This is the big revelation and point of contention with the traditional understanding. Free T is being regulated by the HPTA adjusting output of the testicles up or down (or your dose of exogenous T) and SHBG is just a bystander to that process. The effect of SHBG increasing or decreasing is to increase or decrease the total testosterone value associated with a given free T value.</p><p></p><p>Being insulin sensitive would tend to increase SHBG. If free T is equal, this would have the effect of increasing total testosterone.</p><p></p><p>More here:</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/what-external-factors-affect-levels-while-on-trt.25808/post-230356[/URL]</p><p></p><p>[USER=38109]@Cataceous[/USER] please chime in if needed to correct or elaborate on these statements.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 267117, member: 44064"] So there are multiple things that affect SHBG level, and free T is just one of them. Conversely, SHBG is NOT one of the things that regulates the level of free T. This is the big revelation and point of contention with the traditional understanding. Free T is being regulated by the HPTA adjusting output of the testicles up or down (or your dose of exogenous T) and SHBG is just a bystander to that process. The effect of SHBG increasing or decreasing is to increase or decrease the total testosterone value associated with a given free T value. Being insulin sensitive would tend to increase SHBG. If free T is equal, this would have the effect of increasing total testosterone. More here: [URL unfurl="true"]https://www.excelmale.com/forum/threads/what-external-factors-affect-levels-while-on-trt.25808/post-230356[/URL] [USER=38109]@Cataceous[/USER] please chime in if needed to correct or elaborate on these statements. [/QUOTE]
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