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ExcelFemale
HRT in Women
The physiological role of androgens in women
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<blockquote data-quote="madman" data-source="post: 238820" data-attributes="member: 13851"><p><strong>Article highlights </strong></p><p></p><p><em><strong>*Despite being the most abundant sex hormones in women, the potential role and precise mechanism of action of androgens in women are poorly understood</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The significant factors that contribute to this ‘knowledge gap’ include a) the difficulty of dosing androgens with standard laboratory methods, b) the difficulty of taking into account the diurnal and cyclical variations in androgen levels for blood sampling, and c) the uncertainty of what is considered normal in serum androgen levels in women of different ages </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Several studies show that androgen receptors (ARs) are broadly expressed in several female tissues (urogenital tissue, mammary gland, nervous systems, bone, cardiovascular system, adipose tissue, and liver), where they mediate crucial functions and, until recently, were thought to be only targets of estrogen </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Androgen levels change with the menstrual cycle and decrease in the first decades of life, independently of menopause </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Amongst the mechanisms that need further investigation, is the potential role of androgens in regulating pregnancy. Another topic to investigate is the function of AR in several structures of the CNS. involved in cognitive processes. Furthermore, the molecular mechanisms behind decreasing DHEA and DHEAS levels with advancing age are also unclear </strong></em></p><p><em><strong></strong></em></p><p><strong><em>*Other factors, including estrogen’s effect on adrenal androgen production, reciprocal regulation of ARs, and non-classical effects of androgens, remain to be determined </em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 238820, member: 13851"] [B]Article highlights [/B] [I][B]*Despite being the most abundant sex hormones in women, the potential role and precise mechanism of action of androgens in women are poorly understood *The significant factors that contribute to this ‘knowledge gap’ include a) the difficulty of dosing androgens with standard laboratory methods, b) the difficulty of taking into account the diurnal and cyclical variations in androgen levels for blood sampling, and c) the uncertainty of what is considered normal in serum androgen levels in women of different ages *Several studies show that androgen receptors (ARs) are broadly expressed in several female tissues (urogenital tissue, mammary gland, nervous systems, bone, cardiovascular system, adipose tissue, and liver), where they mediate crucial functions and, until recently, were thought to be only targets of estrogen *Androgen levels change with the menstrual cycle and decrease in the first decades of life, independently of menopause *Amongst the mechanisms that need further investigation, is the potential role of androgens in regulating pregnancy. Another topic to investigate is the function of AR in several structures of the CNS. involved in cognitive processes. Furthermore, the molecular mechanisms behind decreasing DHEA and DHEAS levels with advancing age are also unclear [/B][/I] [B][I]*Other factors, including estrogen’s effect on adrenal androgen production, reciprocal regulation of ARs, and non-classical effects of androgens, remain to be determined [/I][/B] [/QUOTE]
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ExcelFemale
HRT in Women
The physiological role of androgens in women
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