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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The metabolic role of prolactin
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<blockquote data-quote="madman" data-source="post: 239811" data-attributes="member: 13851"><p>Very limited data for LPRL in men!</p><p></p><p></p><p><strong>The metabolic role of prolactin: systematic review, meta-analysis and preclinical considerations (2022)</strong></p><p><em>Giovanni Corona, Giulia Rastrelli, Paolo Comeglio, Federica Guaraldi, Diego Mazzatena, Alessandra Sforza , Linda Vignozzib and Mario Maggi</em></p><p><em></em></p><p><em></em></p><p><em>In men, as well as in women, an abnormal increase in PRL levels (HPRL) is associated with hypogonadotropic hypogonadism due to a hyperprolactinemia-induced reduction of gonadotropin-releasing hormone (GnRH) pulsatility [11]<strong>. </strong>In addition, in women, there is a clear phenotype associated with an abnormal PRL elevation (Chiari Frommel syndrome: amenorrhea/galactorrhea) that was formerly described in the early 1950s[12]. <strong>In contrast, in men, besides the hypogonadism-related symptoms and signs, there is no hyperprolactinemia-associated phenotype, and the only, often reported, symptom is severely reduced sexual desire [13,14]. <u>More than ten years ago we originally described, in a large cohort of men consulting for sexual dysfunction, a syndromic condition we termed ‘hypoprolactinemia’ (LPRL)</u> [15].<u> The condition was characterized by the association between low prolactin levels with particular psychological, sexual, and metabolic issues, including anxiety, premature ejaculation, increased glucose levels, and diabetes</u> [15]. However, considering the metabolic effects of PRL, there are conflicting results – obtained in both preclinical and clinical studies – <u>showing that either low or high PRL might be associated with consistent metabolic derangements</u> (see for review in [9,16,17]).</strong></em></p><p></p><p></p><p><strong>15. </strong>Corona G, Mannucci E, Jannini EA, et al. Hypoprolactinemia: a new clinical syndrome in patients with sexual dysfunction. J Sex Med. 2009 May;6(5):1457–1466. ••<strong> first description of hypoprolactinemia syndrome among males</strong></p><p></p><p></p><p></p><p></p><p><em><strong>The concept of LPRL as a clinical entity was introduced quite recently [<u>32</u>] and only a few studies have investigated this condition either in males or females. </strong>The criteria used for the definition of both HPRL and LPRL differ among the studies. The characteristics of control groups differ among studies. Subjects in the HPRL group tend to be younger than those included in the LPRL group, which represents a further source of bias. <strong>The magnitude of observed differences between HPRL/LPRL and controls derived from our meta-analysis is quite small, suggesting that other factors may well play a possible role.<u> Finally, no information on the effect of increasing PRL in patients with LPRL is available</u>. <u>Hence, the reproducibility of our data warrants caution</u>.</strong></em></p><p></p><p></p><p><strong>32.</strong> Corona G, Wu FC, Rastrelli G, et al. Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European male aging study (EMAS). J Sex Med. 2014 Jan;11(1):240–253.</p></blockquote><p></p>
[QUOTE="madman, post: 239811, member: 13851"] Very limited data for LPRL in men! [B]The metabolic role of prolactin: systematic review, meta-analysis and preclinical considerations (2022)[/B] [I]Giovanni Corona, Giulia Rastrelli, Paolo Comeglio, Federica Guaraldi, Diego Mazzatena, Alessandra Sforza , Linda Vignozzib and Mario Maggi In men, as well as in women, an abnormal increase in PRL levels (HPRL) is associated with hypogonadotropic hypogonadism due to a hyperprolactinemia-induced reduction of gonadotropin-releasing hormone (GnRH) pulsatility [11][B]. [/B]In addition, in women, there is a clear phenotype associated with an abnormal PRL elevation (Chiari Frommel syndrome: amenorrhea/galactorrhea) that was formerly described in the early 1950s[12]. [B]In contrast, in men, besides the hypogonadism-related symptoms and signs, there is no hyperprolactinemia-associated phenotype, and the only, often reported, symptom is severely reduced sexual desire [13,14]. [U]More than ten years ago we originally described, in a large cohort of men consulting for sexual dysfunction, a syndromic condition we termed ‘hypoprolactinemia’ (LPRL)[/U] [15].[U] The condition was characterized by the association between low prolactin levels with particular psychological, sexual, and metabolic issues, including anxiety, premature ejaculation, increased glucose levels, and diabetes[/U] [15]. However, considering the metabolic effects of PRL, there are conflicting results – obtained in both preclinical and clinical studies – [U]showing that either low or high PRL might be associated with consistent metabolic derangements[/U] (see for review in [9,16,17]).[/B][/I] [B]15. [/B]Corona G, Mannucci E, Jannini EA, et al. Hypoprolactinemia: a new clinical syndrome in patients with sexual dysfunction. J Sex Med. 2009 May;6(5):1457–1466. ••[B] first description of hypoprolactinemia syndrome among males[/B] [I][B]The concept of LPRL as a clinical entity was introduced quite recently [[U]32[/U]] and only a few studies have investigated this condition either in males or females. [/B]The criteria used for the definition of both HPRL and LPRL differ among the studies. The characteristics of control groups differ among studies. Subjects in the HPRL group tend to be younger than those included in the LPRL group, which represents a further source of bias. [B]The magnitude of observed differences between HPRL/LPRL and controls derived from our meta-analysis is quite small, suggesting that other factors may well play a possible role.[U] Finally, no information on the effect of increasing PRL in patients with LPRL is available[/U]. [U]Hence, the reproducibility of our data warrants caution[/U].[/B][/I] [B]32.[/B] Corona G, Wu FC, Rastrelli G, et al. Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European male aging study (EMAS). J Sex Med. 2014 Jan;11(1):240–253. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The metabolic role of prolactin
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