ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Nutrition and Supplements
The mechanism of action of N-acetylcysteine (NAC)
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 208894" data-attributes="member: 13851"><p><strong>Fig. 5. <u>Two mechanisms by which NAC can increase intracellular Cys levels</u>. In principle, NAC can deliver Cys in direct (grey) and indirect (orange) ways. How NAC enters cells is not fully understood. Anion exchanger 1 (AE1) may play a role in erythrocytes. Following import, NAC is deacetylated by aminoacylase 1 (ACY1), releasing Cys in the process. Alternatively, NAC can deliver Cys indirectly through disulfide exchange with oxidized Cys in the plasma (Cys-S-S-R), to release reduced Cys (Cys-SH), which is then rapidly imported by the neutral amino acid transporter ASCT1. Although direct evidence is lacking, it seems likely that NAC-S-S-Cys can be imported into cells by the system Xc - anion exchanger. Inside the cell, NAC-S-S-Cys is reduced by intracellular disulfide reducing systems, releasing Cys and NAC, the latter being deacetylated into Cys by ACY1.</strong></p><p><strong>[ATTACH=full]16734[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 208894, member: 13851"] [B]Fig. 5. [U]Two mechanisms by which NAC can increase intracellular Cys levels[/U]. In principle, NAC can deliver Cys in direct (grey) and indirect (orange) ways. How NAC enters cells is not fully understood. Anion exchanger 1 (AE1) may play a role in erythrocytes. Following import, NAC is deacetylated by aminoacylase 1 (ACY1), releasing Cys in the process. Alternatively, NAC can deliver Cys indirectly through disulfide exchange with oxidized Cys in the plasma (Cys-S-S-R), to release reduced Cys (Cys-SH), which is then rapidly imported by the neutral amino acid transporter ASCT1. Although direct evidence is lacking, it seems likely that NAC-S-S-Cys can be imported into cells by the system Xc - anion exchanger. Inside the cell, NAC-S-S-Cys is reduced by intracellular disulfide reducing systems, releasing Cys and NAC, the latter being deacetylated into Cys by ACY1. [ATTACH type="full"]16734[/ATTACH][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Nutrition and Supplements
The mechanism of action of N-acetylcysteine (NAC)
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top