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General Health & Fitness
Nutrition and Supplements
The mechanism of action of N-acetylcysteine (NAC)
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<blockquote data-quote="madman" data-source="post: 208890" data-attributes="member: 13851"><p><strong>Fig. 2. <u>The three classical narratives of how NAC exerts its biological effects</u>. Three narratives have been cultivated in the literature to explain the observed biological effects of NAC. The <u>disulfide reductant</u> narrative postulates that the beneficial effects of NAC are due to its capacity to reduce extra- and/or intracellular disulfide bonds. The <u>oxidant scavenger </u>narrative argues that the NAC sulfhydryl group (highlighted in red) is effective in removing one- and two-electron oxidants, such as hydrogen peroxide (H2O2), hypochlorous acid (HOCl), or hydroxyl radicals (•OH). The <u>glutathione replenishment</u> narrative proposes that NAC delivers Cys for GSH synthesis, hence boosting GSH levels</strong></p><p><strong>[ATTACH=full]16730[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 208890, member: 13851"] [B]Fig. 2. [U]The three classical narratives of how NAC exerts its biological effects[/U]. Three narratives have been cultivated in the literature to explain the observed biological effects of NAC. The [U]disulfide reductant[/U] narrative postulates that the beneficial effects of NAC are due to its capacity to reduce extra- and/or intracellular disulfide bonds. The [U]oxidant scavenger [/U]narrative argues that the NAC sulfhydryl group (highlighted in red) is effective in removing one- and two-electron oxidants, such as hydrogen peroxide (H2O2), hypochlorous acid (HOCl), or hydroxyl radicals (•OH). The [U]glutathione replenishment[/U] narrative proposes that NAC delivers Cys for GSH synthesis, hence boosting GSH levels [ATTACH type="full"]16730[/ATTACH][/B] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
The mechanism of action of N-acetylcysteine (NAC)
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