ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
The KiNG of reproduction: kisspeptin/ nNOS interactions shaping hypothalamic GnRH release
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 200846" data-attributes="member: 13851"><p><strong>Figure 1. Development of GnRH neuronal network. Postnatal development in rodents can be divided into four stages, all marked by developmental events: the neonatal (P0-P7), infantile (P8-P21), juvenile (P22-P30), and peripubertal period, ending with the initiation of puberty. GnRH peptide is already secreted at birth and it increases sharply during the second week of life marking the first postnatal activation of the hypothalamic-pituitary-gonadal (HPG) axis, known as mini puberty. The high levels of circulating estrogens, along with the lack of negative feedback on the neonatal GnRH pulse generator allows for the increase in the FSH levels until the completion of the infantile stage. With the initiation of puberty, the positive feedback action of gonadal steroids eventually results in the GnRH/LH surge. nNOS and kisspeptin neurons also follow distinct maturational patterns. nNOS immunoreactivity (ir) in the preoptic area (POA), within the organum vasculosum laminae terminalis (OV) and the median preoptic nucleus (MePO), is already observed at birth, remaining constant during development. Contrary to the nNOS-ir, the catalytic activity of the nNOS enzyme, marked by the levels of the nNOS phosphorylation on the positive regulatory site serine-1412, significantly increases concomitantly with mini puberty. During adulthood, nNOS phosphorylation significantly increases in proestrus, concomitant with the preovulatory increase in estrogen levels. In the arcuate hypothalamic nucleus (ARH) nNOS-ir appears only after the peak of mini puberty, being visible by the end 4 of the infantile stage. Kisspeptin-ir is already present at birth in the ARH, reaching adult levels before the end of the infantile period. In the POA, within the region of the anteroventral periventricular nucleus (AVPV), the first evidence of kisspeptin-ir is found around mini puberty, with a massive increase in the following days, followed by a steady increase until the end of the juvenile period. Adapted from Messina et al., 2016.</strong></p><p><strong>[ATTACH=full]14124[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 200846, member: 13851"] [B]Figure 1. Development of GnRH neuronal network. Postnatal development in rodents can be divided into four stages, all marked by developmental events: the neonatal (P0-P7), infantile (P8-P21), juvenile (P22-P30), and peripubertal period, ending with the initiation of puberty. GnRH peptide is already secreted at birth and it increases sharply during the second week of life marking the first postnatal activation of the hypothalamic-pituitary-gonadal (HPG) axis, known as mini puberty. The high levels of circulating estrogens, along with the lack of negative feedback on the neonatal GnRH pulse generator allows for the increase in the FSH levels until the completion of the infantile stage. With the initiation of puberty, the positive feedback action of gonadal steroids eventually results in the GnRH/LH surge. nNOS and kisspeptin neurons also follow distinct maturational patterns. nNOS immunoreactivity (ir) in the preoptic area (POA), within the organum vasculosum laminae terminalis (OV) and the median preoptic nucleus (MePO), is already observed at birth, remaining constant during development. Contrary to the nNOS-ir, the catalytic activity of the nNOS enzyme, marked by the levels of the nNOS phosphorylation on the positive regulatory site serine-1412, significantly increases concomitantly with mini puberty. During adulthood, nNOS phosphorylation significantly increases in proestrus, concomitant with the preovulatory increase in estrogen levels. In the arcuate hypothalamic nucleus (ARH) nNOS-ir appears only after the peak of mini puberty, being visible by the end 4 of the infantile stage. Kisspeptin-ir is already present at birth in the ARH, reaching adult levels before the end of the infantile period. In the POA, within the region of the anteroventral periventricular nucleus (AVPV), the first evidence of kisspeptin-ir is found around mini puberty, with a massive increase in the following days, followed by a steady increase until the end of the juvenile period. Adapted from Messina et al., 2016. [ATTACH type="full"]14124[/ATTACH][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
The KiNG of reproduction: kisspeptin/ nNOS interactions shaping hypothalamic GnRH release
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top