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General Health & Fitness
Nutrition and Supplements
The Importance of the Fatty Acid Transporter L-Carnitine in (NAFLD)
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<blockquote data-quote="madman" data-source="post: 183154" data-attributes="member: 13851"><p>[ATTACH=full]10217[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Figure 3.</span> <span style="color: rgb(44, 130, 201)">Simplified schematic of the processes in Non-Alcoholic Fatty Liver Disease</span> <span style="color: rgb(184, 49, 47)">(NAFLD)</span><span style="color: rgb(44, 130, 201)"> with and without L-carnitine treatment.</span> <span style="color: rgb(184, 49, 47)">Left is an illustration of a fatty liver</span>, where there is reduced oxidation of fatty acids (FA) [113], which results in accumulation of FA [114], that can lead to a less functioning liver, with elevated liver enzymes [115], possibly resulting in poor biosynthesis of L-carnitine in the liver [29], which has a negative feedback loop on the transport of FA into the mitochondria. Furthermore, patients with NAFLD have inhibited pyruvate dehydrogenase (PDH) flux [116]. <span style="color: rgb(184, 49, 47)">Right is an illustration of a fatty liver treated with L-carnitine. </span>L-carnitine treatment will improve the transport of long-chain FA to the mitochondria, which will increase the oxidation of FA and therefore reduce the accumulation of fat in the liver [11,71]. By having less fat in the liver, the biosynthesis of L-carnitine will not be inhibited by the liver, and it will have a positive feedback loop and improve the transport of FA to the mitochondria by L-carnitine. L-carnitine will, therefore, reduce liver enzymes and improve liver function [11]. L-carnitine treatment stimulates PDH flux by improving the acetyl-CoA/CoA ratio [101]. </strong></p></blockquote><p></p>
[QUOTE="madman, post: 183154, member: 13851"] [ATTACH type="full"]10217[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Figure 3.[/COLOR] [COLOR=rgb(44, 130, 201)]Simplified schematic of the processes in Non-Alcoholic Fatty Liver Disease[/COLOR] [COLOR=rgb(184, 49, 47)](NAFLD)[/COLOR][COLOR=rgb(44, 130, 201)] with and without L-carnitine treatment.[/COLOR][COLOR=rgb(26, 188, 156)] [/COLOR][COLOR=rgb(184, 49, 47)]Left is an illustration of a fatty liver[/COLOR], where there is reduced oxidation of fatty acids (FA) [113], which results in accumulation of FA [114], that can lead to a less functioning liver, with elevated liver enzymes [115], possibly resulting in poor biosynthesis of L-carnitine in the liver [29], which has a negative feedback loop on the transport of FA into the mitochondria. Furthermore, patients with NAFLD have inhibited pyruvate dehydrogenase (PDH) flux [116]. [COLOR=rgb(184, 49, 47)]Right is an illustration of a fatty liver treated with L-carnitine. [/COLOR]L-carnitine treatment will improve the transport of long-chain FA to the mitochondria, which will increase the oxidation of FA and therefore reduce the accumulation of fat in the liver [11,71]. By having less fat in the liver, the biosynthesis of L-carnitine will not be inhibited by the liver, and it will have a positive feedback loop and improve the transport of FA to the mitochondria by L-carnitine. L-carnitine will, therefore, reduce liver enzymes and improve liver function [11]. L-carnitine treatment stimulates PDH flux by improving the acetyl-CoA/CoA ratio [101]. [/B] [/QUOTE]
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The Importance of the Fatty Acid Transporter L-Carnitine in (NAFLD)
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