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General Health & Fitness
Nutrition and Supplements
The Importance of the Fatty Acid Transporter L-Carnitine in (NAFLD)
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<blockquote data-quote="madman" data-source="post: 183152" data-attributes="member: 13851"><p>[ATTACH=full]10215[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Figure 2. </span><span style="color: rgb(44, 130, 201)">The L-carnitine shuttle.</span> L-carnitine binds to acyl-CoA to help transportation to the mitochondria for β-oxidation. L-carnitine also binds to excess acetyl-CoA to be exported from the mitochondria. The outer mitochondrial membrane contains Carnitine Acyltransferase I/Carnitine Palmitoyl Transferase <span style="color: rgb(184, 49, 47)">(CAT I/CPT I)</span>, that binds L-carnitine to acyl-CoA. Acyl-carnitine can then enter the intermembrane space of the mitochondria. The inner mitochondrial membrane contains Carnitine Acyl Carnitine Translocase <span style="color: rgb(184, 49, 47)">(CACT)</span>, which both can transport acyl-carnitine into the mitochondrial matrix, and can export L-carnitine. The inter mitochondrial membrane also contains Carnitine Acyl Transferase II/Carnitine Palmitoyl Transferase II <span style="color: rgb(184, 49, 47)">(CAT II/CPT II)</span>, which can separate L-carnitine from the acyl-CoA, so that it can undergo β-oxidation. L-carnitine can also bind to acetyl-CoA forming acetyl-carnitine in the mitochondrial matrix, which allows for the export of acetyl-CoA, if not used for oxidative phosphorylation or ketone production. Figure created in BioRender.com </strong></p></blockquote><p></p>
[QUOTE="madman, post: 183152, member: 13851"] [ATTACH type="full" alt="Screenshot (1700).png"]10215[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Figure 2. [/COLOR][COLOR=rgb(44, 130, 201)]The L-carnitine shuttle.[/COLOR] L-carnitine binds to acyl-CoA to help transportation to the mitochondria for β-oxidation. L-carnitine also binds to excess acetyl-CoA to be exported from the mitochondria. The outer mitochondrial membrane contains Carnitine Acyltransferase I/Carnitine Palmitoyl Transferase [COLOR=rgb(184, 49, 47)](CAT I/CPT I)[/COLOR], that binds L-carnitine to acyl-CoA. Acyl-carnitine can then enter the intermembrane space of the mitochondria. The inner mitochondrial membrane contains Carnitine Acyl Carnitine Translocase [COLOR=rgb(184, 49, 47)](CACT)[/COLOR], which both can transport acyl-carnitine into the mitochondrial matrix, and can export L-carnitine. The inter mitochondrial membrane also contains Carnitine Acyl Transferase II/Carnitine Palmitoyl Transferase II [COLOR=rgb(184, 49, 47)](CAT II/CPT II)[/COLOR], which can separate L-carnitine from the acyl-CoA, so that it can undergo β-oxidation. L-carnitine can also bind to acetyl-CoA forming acetyl-carnitine in the mitochondrial matrix, which allows for the export of acetyl-CoA, if not used for oxidative phosphorylation or ketone production. Figure created in BioRender.com [/B] [/QUOTE]
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The Importance of the Fatty Acid Transporter L-Carnitine in (NAFLD)
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