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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The impact of thyroid diseases starting from birth on reproductive function
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<blockquote data-quote="madman" data-source="post: 163737" data-attributes="member: 13851"><p>[ATTACH=full]8674[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Fig. 2 </span>Thyroid hormone physiology. Circulating thyroid hormone concentrations are regulated via a negative feedback system at the level of the hypothalamus and the pituitary.The production of thyroid hormone by the thyroid is regulated by thyroid-stimulating hormone (TSH) produced by the anterior pituitary, which itself is regulated by thyrotropin-releasing hormone (TRH) produced by the hypothalamus. Thyroid hormone circulates as the inactive prohormone thyroxine (T4) and as the active hormone triiodothyronine (T3). Thyroid hormone can enter target cells only by virtue of specific transporters (MCT8, MCT10, andOatpIcl). In target cells, thyroid hormone can be activated (T4toT3) or inactivated (T4 to rT3 or T3 to T2), depending on the local activity of specific deiodinases (D1, D2, and D3). Subsequently, active T3 can bind to the nuclear thyroid hormone receptors (TR-alpha and TR-beta) and induce transcription. Reproduced from Vissenberg R et al. [79], with permission.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 163737, member: 13851"] [ATTACH=full]8674[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Fig. 2 [/COLOR]Thyroid hormone physiology. Circulating thyroid hormone concentrations are regulated via a negative feedback system at the level of the hypothalamus and the pituitary.The production of thyroid hormone by the thyroid is regulated by thyroid-stimulating hormone (TSH) produced by the anterior pituitary, which itself is regulated by thyrotropin-releasing hormone (TRH) produced by the hypothalamus. Thyroid hormone circulates as the inactive prohormone thyroxine (T4) and as the active hormone triiodothyronine (T3). Thyroid hormone can enter target cells only by virtue of specific transporters (MCT8, MCT10, andOatpIcl). In target cells, thyroid hormone can be activated (T4toT3) or inactivated (T4 to rT3 or T3 to T2), depending on the local activity of specific deiodinases (D1, D2, and D3). Subsequently, active T3 can bind to the nuclear thyroid hormone receptors (TR-alpha and TR-beta) and induce transcription. Reproduced from Vissenberg R et al. [79], with permission.[/B] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The impact of thyroid diseases starting from birth on reproductive function
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