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Health & Wellness
The Impact of Step Reduction on Muscle Health in Aging: Protein and Exercise as Countermeasures
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<blockquote data-quote="madman" data-source="post: 149463" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">Figure 2</span></strong><span style="color: rgb(184, 49, 47)">.</span><strong> Physical inactivity models used in human skeletal muscle metabolism. Typical sarcopenic muscle loss based on population estimates (<a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B24" target="_blank">24</a>). Sedentary behavior as categorized by Walhin et al. as < 4000 steps per day induced significant insulin resistance in healthy young adults (<a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B25" target="_blank">25</a>). Interestingly, during one week of bed rest, participants walked for ~22 minutes per day (~2000 steps) in an effort to offset bed rest induced muscle atrophy however exercise was not able to mediate this effect and muscle loss was similar to controls (<a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B26" target="_blank">26</a>). Step reduction, or abruptly reducing habitual daily steps to 750-1500 steps per day results in leg lean mass loss over two weeks in healthy young and older adults (<a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B13" target="_blank">13</a>, <a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B14" target="_blank">14</a>, <a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B27" target="_blank">27</a>). Bed rest induces rapid muscle atrophy in healthy older adults (<a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B9" target="_blank">9</a>) however the rate of muscle loss per day as a result of space flight or exposure to microgravity are staggering (<a href="https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B28" target="_blank">28</a>). </strong></p><p>[ATTACH=full]7507[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 149463, member: 13851"] [B][COLOR=rgb(184, 49, 47)]Figure 2[/COLOR][/B][COLOR=rgb(184, 49, 47)].[/COLOR][B] Physical inactivity models used in human skeletal muscle metabolism. Typical sarcopenic muscle loss based on population estimates ([URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B24']24[/URL]). Sedentary behavior as categorized by Walhin et al. as < 4000 steps per day induced significant insulin resistance in healthy young adults ([URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B25']25[/URL]). Interestingly, during one week of bed rest, participants walked for ~22 minutes per day (~2000 steps) in an effort to offset bed rest induced muscle atrophy however exercise was not able to mediate this effect and muscle loss was similar to controls ([URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B26']26[/URL]). Step reduction, or abruptly reducing habitual daily steps to 750-1500 steps per day results in leg lean mass loss over two weeks in healthy young and older adults ([URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B13']13[/URL], [URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B14']14[/URL], [URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B27']27[/URL]). Bed rest induces rapid muscle atrophy in healthy older adults ([URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B9']9[/URL]) however the rate of muscle loss per day as a result of space flight or exposure to microgravity are staggering ([URL='https://www.frontiersin.org/articles/10.3389/fnut.2019.00075/full?fbclid=IwAR2ePEELO8N4hGYe5CWfCGq8a3qmnNHnFxN_BhfhkRIiJodcY8kkQCLNdak#B28']28[/URL]). [/B] [ATTACH=full]7507[/ATTACH] [/QUOTE]
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The Impact of Step Reduction on Muscle Health in Aging: Protein and Exercise as Countermeasures
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