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The estrogenic activity of resveratrol:
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<blockquote data-quote="madman" data-source="post: 183642" data-attributes="member: 13851"><p>[ATTACH=full]10296[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Figure 2.</span> <span style="color: rgb(44, 130, 201)">Enzymatic targets of resveratrol in the pathways of steroid hormone biosynthesis and metabolism.</span> The targets are outlined in bold and have been described in various literature reports. Details of the effects of resveratrol on these enzymes and inhibitory concentrations are mentioned in the text. Not shown but described in the text is the enzymatic reduction of estrogenic quinones to E1 and E2 catechols via quinone reductase <span style="color: rgb(184, 49, 47)">(NQO1)</span> and their subsequent elimination via phase II conjugation reactions. Resveratrol induces the expression of NQO1, therefore, protecting against the formation of reactive quinones. The effect of resveratrol on the catalytic activity of CYP1A2 has been inconsistent with reports of enhanced and suppressed phenotypic activities. The hydroxylation of estrogens into catechol derivatives <span style="color: rgb(184, 49, 47)">(2-OHE1(E2) and 4-OHE1(E2))</span> is presumed for E1 and E2 and the full chemical structures of the catechol estrogens have been abbreviated to display enzymatic modifications on the A ring. <span style="color: rgb(44, 130, 201)">StAR: </span><span style="color: rgb(184, 49, 47)">steroidogenic acute regulatory protein that carries mitochondrial import of cholesterol. </span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 183642, member: 13851"] [ATTACH type="full"]10296[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Figure 2.[/COLOR] [COLOR=rgb(44, 130, 201)]Enzymatic targets of resveratrol in the pathways of steroid hormone biosynthesis and metabolism.[/COLOR] The targets are outlined in bold and have been described in various literature reports. Details of the effects of resveratrol on these enzymes and inhibitory concentrations are mentioned in the text. Not shown but described in the text is the enzymatic reduction of estrogenic quinones to E1 and E2 catechols via quinone reductase [COLOR=rgb(184, 49, 47)](NQO1)[/COLOR] and their subsequent elimination via phase II conjugation reactions. Resveratrol induces the expression of NQO1, therefore, protecting against the formation of reactive quinones. The effect of resveratrol on the catalytic activity of CYP1A2 has been inconsistent with reports of enhanced and suppressed phenotypic activities. The hydroxylation of estrogens into catechol derivatives [COLOR=rgb(184, 49, 47)](2-OHE1(E2) and 4-OHE1(E2))[/COLOR] is presumed for E1 and E2 and the full chemical structures of the catechol estrogens have been abbreviated to display enzymatic modifications on the A ring. [COLOR=rgb(44, 130, 201)]StAR: [/COLOR][COLOR=rgb(184, 49, 47)]steroidogenic acute regulatory protein that carries mitochondrial import of cholesterol. [/COLOR][/B] [/QUOTE]
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The estrogenic activity of resveratrol:
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