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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers
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<blockquote data-quote="Nelson Vergel" data-source="post: 134775" data-attributes="member: 3"><p>Send to</p><p>Psychopharmacology (Berl). 2018 Dec;235(12):3415-3422. doi: 10.1007/s00213-018-5050-1. Epub 2018 Oct 3.</p><p></p><p><strong><span style="font-size: 18px">The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers</span></strong></p><p></p><p>Ronaldson A1, Carvalho LA2, Kostich K3, Lazzarino AI3, Urbanova L3, Steptoe A3.</p><p></p><p>Abstract</p><p>RATIONALE:</p><p>Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been widely reported in depression, and evidence suggests that selective serotonin reuptake inhibitors (SSRIs) might exert their therapeutic effects through altering cortisol secretion.</p><p></p><p>OBJECTIVE:</p><p>This study assessed the effects of SSRI administration on diurnal cortisol secretion in healthy volunteers.</p><p></p><p>METHODS:</p><p>Sixty-four healthy men and women were randomised to receive either 10 mg escitalopram or placebo for six days in a double-blind fashion. On day six of medication, saliva samples were obtained at home for measurement of diurnal cortisol parameters (cortisol slope, cortisol awakening response, total daily cortisol output).</p><p></p><p>RESULTS:</p><p>Women receiving escitalopram had significantly steeper cortisol slopes across the day compared with those receiving placebo (F(1, 36) = 7.54, p = 0.009). This alteration in cortisol slope was driven by increases in waking cortisol levels (F(1, 35) = 9.21, p = 0.005). Escitalopram did not have any significant effect on the cortisol awakening response or the total daily cortisol output.</p><p></p><p>CONCLUSIONS:</p><p>Flattened cortisol slopes have been seen in depression. The results of this study suggest that escitalopram might exert its therapeutic effect in women in part through correction of a flattened diurnal cortisol rhythm.</p><p></p><p>KEYWORDS:</p><p>Antidepressants; Cortisol; Depression; Escitalopram; HPA axis; SSRIs</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 134775, member: 3"] Send to Psychopharmacology (Berl). 2018 Dec;235(12):3415-3422. doi: 10.1007/s00213-018-5050-1. Epub 2018 Oct 3. [B][SIZE=18px]The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers[/SIZE][/B] Ronaldson A1, Carvalho LA2, Kostich K3, Lazzarino AI3, Urbanova L3, Steptoe A3. Abstract RATIONALE: Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been widely reported in depression, and evidence suggests that selective serotonin reuptake inhibitors (SSRIs) might exert their therapeutic effects through altering cortisol secretion. OBJECTIVE: This study assessed the effects of SSRI administration on diurnal cortisol secretion in healthy volunteers. METHODS: Sixty-four healthy men and women were randomised to receive either 10 mg escitalopram or placebo for six days in a double-blind fashion. On day six of medication, saliva samples were obtained at home for measurement of diurnal cortisol parameters (cortisol slope, cortisol awakening response, total daily cortisol output). RESULTS: Women receiving escitalopram had significantly steeper cortisol slopes across the day compared with those receiving placebo (F(1, 36) = 7.54, p = 0.009). This alteration in cortisol slope was driven by increases in waking cortisol levels (F(1, 35) = 9.21, p = 0.005). Escitalopram did not have any significant effect on the cortisol awakening response or the total daily cortisol output. CONCLUSIONS: Flattened cortisol slopes have been seen in depression. The results of this study suggest that escitalopram might exert its therapeutic effect in women in part through correction of a flattened diurnal cortisol rhythm. KEYWORDS: Antidepressants; Cortisol; Depression; Escitalopram; HPA axis; SSRIs [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers
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