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The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults
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<blockquote data-quote="madman" data-source="post: 188448" data-attributes="member: 13851"><p><strong>The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: <span style="color: rgb(184, 49, 47)">a systematic review and meta-analysis of randomized controlled trials </span></strong></p><p><strong><span style="color: rgb(184, 49, 47)"></span></strong></p><p><strong><span style="color: rgb(184, 49, 47)"></span></strong></p><p><strong><span style="color: rgb(184, 49, 47)"></span></strong></p><p><strong><span style="color: rgb(184, 49, 47)"></span></strong></p><p><strong><span style="color: rgb(184, 49, 47)">ABSTRACT </span></strong></p><p><strong></strong></p><p><strong>Background and aims:</strong> <em><span style="color: rgb(184, 49, 47)">During the last decades, there has been a burst of scientific literature hypothesizing the antioxidant effect of probiotics. However, the results of these studies are inconsistent and a final conclusion has yet to be reached. Thus, the aim of this study was to assess the effects of probiotic/synbiotic supplementation on serum total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels in adults. </span></em></p><p></p><p><strong>Methods and Results:</strong> The following online databases were searched until August 26th, 2020: PubMed/Medline, Scopus, Clarivate Analytics Web of Science, Cochrane Central Register of Controlled Trials, Science Direct, Google Scholar, and Igaku Chuo Zasshi. The effect sizes were expressed as the weighted mean difference (WMD) with 95% confidence intervals (CI). A total of 31 eligible trials with 1681 participants (839 cases and 842 controls) were included in this meta-analysis. <span style="color: rgb(184, 49, 47)"><em>The results revealed that the supplementation with probiotics/synbiotics, significantly increased serum TAC (WMD: 54.14 mmol/L, 95% CI: 27.87, 80.40, P < 0.001), GSH (WMD: 40.38 μ mol/L, 95% CI: 20.72, 60.03, P < 0.001) and NO (WMD: 3.54 μmol/L, 95% CI: 1.73, 5.34, P < 0.001) levels. In addition, MDA levels were significantly reduced (WMD: -0.45 μmol/L, 95% CI: -0.58,-0.32, P < 0.001) following probiotic/synbiotic supplementation.</em></span> None of the variables showed a significant change in the sensitivity analysis.</p><p></p><p><strong>Conclusion:</strong> <em><span style="color: rgb(184, 49, 47)">Available evidence suggests that probiotic/synbiotic supplementation can significantly increase serum TAC, GSH, and NO, as well as reduce MDA levels in adults.</span><span style="color: rgb(44, 130, 201)"> Therefore, probiotic/synbiotic supplementation may play a role in improving antioxidant indices and reducing oxidative stress in the body.</span></em></p><p></p><p></p><p></p><p></p><p><strong>Highlights </strong></p><p><strong></strong></p><p><strong>*</strong><span style="color: rgb(184, 49, 47)">Probiotics/synbiotics are said to play a role in improving antioxidant indices and reducing oxidative stress levels in the body. </span></p><p></p><p><strong>*</strong><span style="color: rgb(184, 49, 47)">We reviewed the effects of probiotic/synbiotic supplementation on several oxidative stress biomarkers in adults. </span></p><p></p><p><strong>*</strong><span style="color: rgb(184, 49, 47)"><strong>According to our findings, probiotic/synbiotic supplementation significantly increased serum glutathione (GSH), nitric oxide (NO), and the total antioxidant capacity (TAC) and significantly reduced malondialdehyde (MDA) levels in the body. </strong></span></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusion </strong></p><p><strong></strong></p><p><strong><em><span style="color: rgb(184, 49, 47)">The results of our meta-analysis show that probiotic/synbiotic supplementation can significantly increase serum TAC, GSH, and NO, as well as reduce MDA levels in adults. </span></em></strong><em><strong><span style="color: rgb(44, 130, 201)">In addition, the results of this analysis showed a significant increase in TAC and NO in subjects aged ≤ 50 years versus subjects aged >50 years. In the participants with a BMI of 25–29.9 kg/m2, TAC, NO, and GSH levels significantly increased versus subjects with other BMI ranges. In addition, the increase in NO levels was also significant when the intervention exceeded 8 weeks.</span></strong></em> <em><strong><span style="color: rgb(184, 49, 47)">Therefore, probiotic/synbiotic supplementation might be effective in reducing oxidative stress levels and thus preventing or ameliorating diabetes, cardiovascular disease, cancer, and other chronic diseases.</span></strong></em> <strong><em><span style="color: rgb(44, 130, 201)">However, for accuracy and higher generalizability of the results, future investigations, with larger sample sizes, different populations (including healthy subjects), doses, and probiotic strains are required in order to clarify the effect of probiotic/synbiotic supplementation on oxidative stress biomarkers. </span></em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 188448, member: 13851"] [B]The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: [COLOR=rgb(184, 49, 47)]a systematic review and meta-analysis of randomized controlled trials ABSTRACT [/COLOR] Background and aims:[/B] [I][COLOR=rgb(184, 49, 47)]During the last decades, there has been a burst of scientific literature hypothesizing the antioxidant effect of probiotics. However, the results of these studies are inconsistent and a final conclusion has yet to be reached. Thus, the aim of this study was to assess the effects of probiotic/synbiotic supplementation on serum total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels in adults. [/COLOR][/I] [B]Methods and Results:[/B] The following online databases were searched until August 26th, 2020: PubMed/Medline, Scopus, Clarivate Analytics Web of Science, Cochrane Central Register of Controlled Trials, Science Direct, Google Scholar, and Igaku Chuo Zasshi. The effect sizes were expressed as the weighted mean difference (WMD) with 95% confidence intervals (CI). A total of 31 eligible trials with 1681 participants (839 cases and 842 controls) were included in this meta-analysis. [COLOR=rgb(184, 49, 47)][I]The results revealed that the supplementation with probiotics/synbiotics, significantly increased serum TAC (WMD: 54.14 mmol/L, 95% CI: 27.87, 80.40, P < 0.001), GSH (WMD: 40.38 μ mol/L, 95% CI: 20.72, 60.03, P < 0.001) and NO (WMD: 3.54 μmol/L, 95% CI: 1.73, 5.34, P < 0.001) levels. In addition, MDA levels were significantly reduced (WMD: -0.45 μmol/L, 95% CI: -0.58,-0.32, P < 0.001) following probiotic/synbiotic supplementation.[/I][/COLOR] None of the variables showed a significant change in the sensitivity analysis. [B]Conclusion:[/B] [I][COLOR=rgb(184, 49, 47)]Available evidence suggests that probiotic/synbiotic supplementation can significantly increase serum TAC, GSH, and NO, as well as reduce MDA levels in adults.[/COLOR][COLOR=rgb(44, 130, 201)] Therefore, probiotic/synbiotic supplementation may play a role in improving antioxidant indices and reducing oxidative stress in the body.[/COLOR][/I] [B]Highlights *[/B][COLOR=rgb(184, 49, 47)]Probiotics/synbiotics are said to play a role in improving antioxidant indices and reducing oxidative stress levels in the body. [/COLOR] [B]*[/B][COLOR=rgb(184, 49, 47)]We reviewed the effects of probiotic/synbiotic supplementation on several oxidative stress biomarkers in adults. [/COLOR] [B]*[/B][COLOR=rgb(184, 49, 47)][B]According to our findings, probiotic/synbiotic supplementation significantly increased serum glutathione (GSH), nitric oxide (NO), and the total antioxidant capacity (TAC) and significantly reduced malondialdehyde (MDA) levels in the body. [/B][/COLOR] [B]Conclusion [I][COLOR=rgb(184, 49, 47)]The results of our meta-analysis show that probiotic/synbiotic supplementation can significantly increase serum TAC, GSH, and NO, as well as reduce MDA levels in adults. [/COLOR][/I][/B][I][B][COLOR=rgb(44, 130, 201)]In addition, the results of this analysis showed a significant increase in TAC and NO in subjects aged ≤ 50 years versus subjects aged >50 years. In the participants with a BMI of 25–29.9 kg/m2, TAC, NO, and GSH levels significantly increased versus subjects with other BMI ranges. In addition, the increase in NO levels was also significant when the intervention exceeded 8 weeks.[/COLOR][/B][/I] [I][B][COLOR=rgb(184, 49, 47)]Therefore, probiotic/synbiotic supplementation might be effective in reducing oxidative stress levels and thus preventing or ameliorating diabetes, cardiovascular disease, cancer, and other chronic diseases.[/COLOR][/B][/I] [B][I][COLOR=rgb(44, 130, 201)]However, for accuracy and higher generalizability of the results, future investigations, with larger sample sizes, different populations (including healthy subjects), doses, and probiotic strains are required in order to clarify the effect of probiotic/synbiotic supplementation on oxidative stress biomarkers. [/COLOR][/I][/B] [/QUOTE]
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The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults
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