ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
General Health & Fitness
Nutrition and Supplements
The Effects of Creatine Supplementation
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="BadassBlues" data-source="post: 262690" data-attributes="member: 38526"><p>Creatine supplementation can lead to a false positive test result due to conversion to creatinine. There is a lot of junk theory that creatine supplementation can harm <strong><em>normal kidney function. </em></strong>If a person has underlying kidney problems or a predisposition to kidney problems (genetic / hereditary), then it would be prudent to perhaps avoid taking supplemental creatine.</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/30367015/[/URL]</p><p></p><h3>Potential Adverse Effects of Creatine Supplement on the Kidney in Athletes and Bodybuilders</h3><p><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Davani-Davari+D&cauthor_id=30367015" target="_blank">Dorna Davani-Davari</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Karimzadeh+I&cauthor_id=30367015" target="_blank">Iman Karimzadeh</a> <a href="https://pubmed.ncbi.nlm.nih.gov/30367015/#full-view-affiliation-1" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Ezzatzadegan-Jahromi+S&cauthor_id=30367015" target="_blank">Shahrokh Ezzatzadegan-Jahromi</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Sagheb+MM&cauthor_id=30367015" target="_blank">Mohammad Mahdi Sagheb</a></p><p>Affiliations expand</p><ul> <li data-xf-list-type="ul">PMID: <strong>30367015</strong></li> </ul><p>Free article</p><h3>Abstract</h3><p><strong>Introduction: </strong>Nowadays, creatine is one of the most common oral supplements used by professional athletes for boosting their strength and muscle mass. In this review, we collect available experimental and clinical data about renal safety of both short-term and long-term use of creatine.</p><p><strong>Materials and methods: </strong>Scientific literature was critically searched by keywords "creatine," "renal insufficiency," and "renal dysfunction" and their synonyms in medical databases (Scopus, MEDLINE, EMBase, and ISI Web of Knowledge). Overall, 19 relevant clinical and experimental articles were selected for this review.</p><p><strong>Results: </strong>Short- and long-term creatine supplementations (range, 5 days to 5 years) with different doses (range, 5 g/d to 30 g/d) had no known significant effects on different studied indexes of kidney function such as glomerular filtration rate at least in healthy athletes and bodybuilders with no underlying kidney diseases. In addition, although short-term (range, 5 days to 2 weeks) high-dose oral creatine supplementation (range, 20 g/d to 0.3 g/kg/d) stimulated the production of methylamine and formaldehyde (as potential cytotoxic metabolites of creatine) in the urine of healthy humans, there was currently no definite clinical evidence about their adverse effects on the kidney function.</p><p><strong>Conclusions: </strong>Although creatine supplementation appears to have no detrimental effects on kidney function of individuals without underlying kidney diseases, it seems more advisable to suggest that creatine supplementation not to be used by sportsmen or women with pre-existing kidney disease or those with a potential risk for kidney dysfunction.</p></blockquote><p></p>
[QUOTE="BadassBlues, post: 262690, member: 38526"] Creatine supplementation can lead to a false positive test result due to conversion to creatinine. There is a lot of junk theory that creatine supplementation can harm [B][I]normal kidney function. [/I][/B]If a person has underlying kidney problems or a predisposition to kidney problems (genetic / hereditary), then it would be prudent to perhaps avoid taking supplemental creatine. [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/30367015/[/URL] [HEADING=2]Potential Adverse Effects of Creatine Supplement on the Kidney in Athletes and Bodybuilders[/HEADING] [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Davani-Davari+D&cauthor_id=30367015']Dorna Davani-Davari[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Karimzadeh+I&cauthor_id=30367015']Iman Karimzadeh[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/30367015/#full-view-affiliation-1']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Ezzatzadegan-Jahromi+S&cauthor_id=30367015']Shahrokh Ezzatzadegan-Jahromi[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Sagheb+MM&cauthor_id=30367015']Mohammad Mahdi Sagheb[/URL] Affiliations expand [LIST] [*]PMID: [B]30367015[/B] [/LIST] Free article [HEADING=2]Abstract[/HEADING] [B]Introduction: [/B]Nowadays, creatine is one of the most common oral supplements used by professional athletes for boosting their strength and muscle mass. In this review, we collect available experimental and clinical data about renal safety of both short-term and long-term use of creatine. [B]Materials and methods: [/B]Scientific literature was critically searched by keywords "creatine," "renal insufficiency," and "renal dysfunction" and their synonyms in medical databases (Scopus, MEDLINE, EMBase, and ISI Web of Knowledge). Overall, 19 relevant clinical and experimental articles were selected for this review. [B]Results: [/B]Short- and long-term creatine supplementations (range, 5 days to 5 years) with different doses (range, 5 g/d to 30 g/d) had no known significant effects on different studied indexes of kidney function such as glomerular filtration rate at least in healthy athletes and bodybuilders with no underlying kidney diseases. In addition, although short-term (range, 5 days to 2 weeks) high-dose oral creatine supplementation (range, 20 g/d to 0.3 g/kg/d) stimulated the production of methylamine and formaldehyde (as potential cytotoxic metabolites of creatine) in the urine of healthy humans, there was currently no definite clinical evidence about their adverse effects on the kidney function. [B]Conclusions: [/B]Although creatine supplementation appears to have no detrimental effects on kidney function of individuals without underlying kidney diseases, it seems more advisable to suggest that creatine supplementation not to be used by sportsmen or women with pre-existing kidney disease or those with a potential risk for kidney dysfunction. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
General Health & Fitness
Nutrition and Supplements
The Effects of Creatine Supplementation
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top