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General Health & Fitness
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The effect of vitamin D supplementation on depressive symptoms in adults
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<blockquote data-quote="BigTex" data-source="post: 269935" data-attributes="member: 43589"><p><h2>Abstract</h2><p>Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta‐analyses investigating the effect of vitamin D on depression have been inconsistent. This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials (RCT). General and clinical populations, and studies of ill individuals with systemic diseases were included. Light therapy, co-supplementation (except calcium) and bipolar disorder were exclusionary. Databases Medline, PsycINFO, CINAHL and The Cochrane Library were searched to identify relevant articles in English published before April 2022. Cochrane risk-of-bias tool (RoB 2) and GRADE were used to appraise studies. Forty-one RCTs (<em>n</em> = 53,235) were included. Analyses based on random-effects models were performed with the Comprehensive Meta-analysis Software. Results for main outcome (<em>n</em> = 53,235) revealed a positive effect of vitamin D on depressive symptoms (Hedges’ <em>g</em> = −0.317, 95% CI [−0.405, −0.230], <em>p</em> < 0.001, I2 = 88.16%; GRADE: very low certainty). RoB assessment was concerning in most studies. <strong>Notwithstanding high heterogeneity, vitamin D supplementation ≥ 2,000 IU/day appears to reduce depressive symptoms.</strong> Future research should investigate possible benefits of augmenting standard treatments with vitamin D in clinical depression. </p><p></p><p>[URL unfurl="true"]https://www.tandfonline.com/doi/full/10.1080/10408398.2022.2096560[/URL]</p></blockquote><p></p>
[QUOTE="BigTex, post: 269935, member: 43589"] [HEADING=1]Abstract[/HEADING] Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta‐analyses investigating the effect of vitamin D on depression have been inconsistent. This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials (RCT). General and clinical populations, and studies of ill individuals with systemic diseases were included. Light therapy, co-supplementation (except calcium) and bipolar disorder were exclusionary. Databases Medline, PsycINFO, CINAHL and The Cochrane Library were searched to identify relevant articles in English published before April 2022. Cochrane risk-of-bias tool (RoB 2) and GRADE were used to appraise studies. Forty-one RCTs ([I]n[/I] = 53,235) were included. Analyses based on random-effects models were performed with the Comprehensive Meta-analysis Software. Results for main outcome ([I]n[/I] = 53,235) revealed a positive effect of vitamin D on depressive symptoms (Hedges’ [I]g[/I] = −0.317, 95% CI [−0.405, −0.230], [I]p[/I] < 0.001, I2 = 88.16%; GRADE: very low certainty). RoB assessment was concerning in most studies. [B]Notwithstanding high heterogeneity, vitamin D supplementation ≥ 2,000 IU/day appears to reduce depressive symptoms.[/B] Future research should investigate possible benefits of augmenting standard treatments with vitamin D in clinical depression. [URL unfurl="true"]https://www.tandfonline.com/doi/full/10.1080/10408398.2022.2096560[/URL] [/QUOTE]
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The effect of vitamin D supplementation on depressive symptoms in adults
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