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Mental Health
The connection of 5AR inhibitors like finasteride to the development of depression
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<blockquote data-quote="madman" data-source="post: 211415" data-attributes="member: 13851"><p><strong><em>*Changes in neuroactive steroids following 5-ARI use can lead to dysfunction of the dopaminergic system, reduction of hippocampal neurogenesis, an increase in neuroinflammation, alterations of the HPA axis, and epigenetic modification. Moreover, the alterations of the neuroactive steroids, especially AP, are also linked to the alteration of central nervous system receptor functions including dopaminergic receptors, GABA-A receptors, estrogen receptors, and androgen receptors</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 211415, member: 13851"] [B][I]*Changes in neuroactive steroids following 5-ARI use can lead to dysfunction of the dopaminergic system, reduction of hippocampal neurogenesis, an increase in neuroinflammation, alterations of the HPA axis, and epigenetic modification. Moreover, the alterations of the neuroactive steroids, especially AP, are also linked to the alteration of central nervous system receptor functions including dopaminergic receptors, GABA-A receptors, estrogen receptors, and androgen receptors[/I][/B] [/QUOTE]
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Mental Health
The connection of 5AR inhibitors like finasteride to the development of depression
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