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Mental Health
The connection of 5AR inhibitors like finasteride to the development of depression
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<blockquote data-quote="madman" data-source="post: 211414" data-attributes="member: 13851"><p><strong>Fig. 3. <u>Summary of potential underlying mechanisms linking 5-alpha reductase inhibitors and depression</u>. The key possible effect of 5-ARIs is an alteration of neuroactive steroids, <u>specifically allopregnanolone and 5-alpha reductase products</u>. <u>The alterations in neuroactive steroids have close causation with the dysfunction of the dopaminergic system and an alteration in brain receptor function</u>. The changes in neuroactive steroids appear to be associated with other underlying mechanisms causing depression in prior 5-ARIs users to include reduction of hippocampal neurogenesis, alterations of HPA axis, and epigenetic modifications. However, 5-ARIs effects themselves can influence systemic inflammation through gut dysbiosis and increase inflammation in the hippocampus. Neuroinflammation is related to depression via the alteration of DA systems and the reduction of hippocampal neurogenesis. Regarding the relationship between sexual dysfunction and depression, it appears that the association is bidirectional. Abbreviations: 5- ARIs: 5-alpha reductase inhibitors; HPA: hypothalamic pituitary adrenal.</strong></p><p><strong>[ATTACH=full]17457[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 211414, member: 13851"] [B]Fig. 3. [U]Summary of potential underlying mechanisms linking 5-alpha reductase inhibitors and depression[/U]. The key possible effect of 5-ARIs is an alteration of neuroactive steroids, [U]specifically allopregnanolone and 5-alpha reductase products[/U]. [U]The alterations in neuroactive steroids have close causation with the dysfunction of the dopaminergic system and an alteration in brain receptor function[/U]. The changes in neuroactive steroids appear to be associated with other underlying mechanisms causing depression in prior 5-ARIs users to include reduction of hippocampal neurogenesis, alterations of HPA axis, and epigenetic modifications. However, 5-ARIs effects themselves can influence systemic inflammation through gut dysbiosis and increase inflammation in the hippocampus. Neuroinflammation is related to depression via the alteration of DA systems and the reduction of hippocampal neurogenesis. Regarding the relationship between sexual dysfunction and depression, it appears that the association is bidirectional. Abbreviations: 5- ARIs: 5-alpha reductase inhibitors; HPA: hypothalamic pituitary adrenal. [ATTACH type="full" alt="Screenshot (8933).png"]17457[/ATTACH][/B] [/QUOTE]
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Mental Health
The connection of 5AR inhibitors like finasteride to the development of depression
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