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The Case Against Coronary Artery Calcium Scoring for Cardiovascular Disease Risk Assessment
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<blockquote data-quote="Nelson Vergel" data-source="post: 244809" data-attributes="member: 3"><p>This is worrisome. Data linking high volume exercise with increased calcium score.</p><p></p><p><strong>Potential mechanisms linking high-volume exercise with coronary artery calcification</strong></p><p></p><p>Angelica Zambrano 1, Yin Tintut 2 3, Linda L Demer 2 3, Jeffrey J Hsu 4 3</p><p>Review Heart . 2023 Jan 26;heartjnl-2022-321986. doi: 10.1136/heartjnl-2022-321986. Online ahead of print.</p><p></p><p>Abstract</p><p>Recent studies have found an association between high volumes of physical activity and increased levels of coronary artery calcification (CAC) among older male endurance athletes, yet the underlying mechanisms have remained largely elusive. Potential mechanisms include greater exposure to inflammatory cytokines, reactive oxygen species and oxidized low-density lipoproteins, as acute strenuous physical activity has been found to enhance their systemic release. Other possibilities include post-exercise elevations in circulating parathyroid hormone, which can modify the amount and morphology of calcific plaque, and long-term exposure to non-laminar blood flow within the coronary arteries during vigorous physical activity, particularly in individuals with pre-existing atherosclerosis. Further, although the association has only been identified in men, the role of testosterone in this process remains unclear. This brief review discusses the association between high-volume endurance exercise and CAC in older men, elaborates on the potential mechanisms underlying the increased calcification, and provides clinical implications and recommendations for those at risk.</p><p></p><p>Keywords: Atherosclerosis; Computed Tomography Angiography; Coronary Artery Disease.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 244809, member: 3"] This is worrisome. Data linking high volume exercise with increased calcium score. [B]Potential mechanisms linking high-volume exercise with coronary artery calcification[/B] Angelica Zambrano 1, Yin Tintut 2 3, Linda L Demer 2 3, Jeffrey J Hsu 4 3 Review Heart . 2023 Jan 26;heartjnl-2022-321986. doi: 10.1136/heartjnl-2022-321986. Online ahead of print. Abstract Recent studies have found an association between high volumes of physical activity and increased levels of coronary artery calcification (CAC) among older male endurance athletes, yet the underlying mechanisms have remained largely elusive. Potential mechanisms include greater exposure to inflammatory cytokines, reactive oxygen species and oxidized low-density lipoproteins, as acute strenuous physical activity has been found to enhance their systemic release. Other possibilities include post-exercise elevations in circulating parathyroid hormone, which can modify the amount and morphology of calcific plaque, and long-term exposure to non-laminar blood flow within the coronary arteries during vigorous physical activity, particularly in individuals with pre-existing atherosclerosis. Further, although the association has only been identified in men, the role of testosterone in this process remains unclear. This brief review discusses the association between high-volume endurance exercise and CAC in older men, elaborates on the potential mechanisms underlying the increased calcification, and provides clinical implications and recommendations for those at risk. Keywords: Atherosclerosis; Computed Tomography Angiography; Coronary Artery Disease. [/QUOTE]
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The Case Against Coronary Artery Calcium Scoring for Cardiovascular Disease Risk Assessment
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