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Mental Health
The Case Against Antidepressants
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<blockquote data-quote="Pnw0031" data-source="post: 260201" data-attributes="member: 45081"><p>After trying straight Allopregnanolone I know I can NEVER take SSRIs. I had a HUGE inverse effect where I was ridiculously angry at nonissues and overreacted to pretty much everything. I had a very minor argument the morning before I received my Allo preg that essentially revolved around someone in my group going too far ahead on a hike while others were struggling behind and they took too long to stop. Fairly minor issue mainly exacerbated by the heat; before taking 5mg allopregnanolone it didn’t really affect me. After taking the allop I started hardcore ruminating and almost called the person in a fit of rage. I felt an unreasonable compulsion to do so. Never have felt anything quite out of control like that. Especially over such a tiny thing. The rest of the day and then night was just me not being able to sleep and wanting to break shit around me. Next day I was late for work because of uncontrollable traffic and I wanted to beat the shit out of my coworkers. Just totally irrational feelings, never have felt this way before. If anything, taking hormones (testosterone cyp) tends to make me feel more mentally stable despite side effects such as insomnia which are slowly being fixed. Not sure what the half life of this stuff is but I want it out of my system ASAP! I mention this on a thread about SSRIs because some ssris (especially lexapro and prozac) increase allopregnanolone which for some may be their saving grace. For me it was absolute hell in one night. </p><p></p><p>Here is the Wikipedia on the inverse reaction from allopregnanolone:</p><p></p><p><a href="https://en.wikipedia.org/wiki/Allopregnanolone" target="_blank">Allopregnanolone - Wikipedia</a></p><p>"...<strong>Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[24][25][26] This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total allopregnanolone, which are approximately equivalent to luteal phase levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it.[24][25] This seems to be a common effect of many GABAA receptor positive allosteric modulators.[26][21] In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels), have been found to have negative effects on mood, while higher doses have a neutral effect</strong>.[27]"</p><p></p><p>Here is an article on SSRIs and allopregnanolone:</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/32435667/[/URL]</p><p></p><p>I don’t mean to doom-post or whatever on SSRIs and allopregnanolone, but I do want to post this as a warning for the absolute mental hell I went through (and still somewhat dealing with about a day later). Taking any kind of hormone is a gamble in itself and allopregnanolone just wasn’t for me.</p></blockquote><p></p>
[QUOTE="Pnw0031, post: 260201, member: 45081"] After trying straight Allopregnanolone I know I can NEVER take SSRIs. I had a HUGE inverse effect where I was ridiculously angry at nonissues and overreacted to pretty much everything. I had a very minor argument the morning before I received my Allo preg that essentially revolved around someone in my group going too far ahead on a hike while others were struggling behind and they took too long to stop. Fairly minor issue mainly exacerbated by the heat; before taking 5mg allopregnanolone it didn’t really affect me. After taking the allop I started hardcore ruminating and almost called the person in a fit of rage. I felt an unreasonable compulsion to do so. Never have felt anything quite out of control like that. Especially over such a tiny thing. The rest of the day and then night was just me not being able to sleep and wanting to break shit around me. Next day I was late for work because of uncontrollable traffic and I wanted to beat the shit out of my coworkers. Just totally irrational feelings, never have felt this way before. If anything, taking hormones (testosterone cyp) tends to make me feel more mentally stable despite side effects such as insomnia which are slowly being fixed. Not sure what the half life of this stuff is but I want it out of my system ASAP! I mention this on a thread about SSRIs because some ssris (especially lexapro and prozac) increase allopregnanolone which for some may be their saving grace. For me it was absolute hell in one night. Here is the Wikipedia on the inverse reaction from allopregnanolone: [URL='https://en.wikipedia.org/wiki/Allopregnanolone']Allopregnanolone - Wikipedia[/URL] "...[B]Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[24][25][26] This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total allopregnanolone, which are approximately equivalent to luteal phase levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it.[24][25] This seems to be a common effect of many GABAA receptor positive allosteric modulators.[26][21] In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels), have been found to have negative effects on mood, while higher doses have a neutral effect[/B].[27]" Here is an article on SSRIs and allopregnanolone: [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/32435667/[/URL] I don’t mean to doom-post or whatever on SSRIs and allopregnanolone, but I do want to post this as a warning for the absolute mental hell I went through (and still somewhat dealing with about a day later). Taking any kind of hormone is a gamble in itself and allopregnanolone just wasn’t for me. [/QUOTE]
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Mental Health
The Case Against Antidepressants
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