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Mental Health
The Case Against Antidepressants
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<blockquote data-quote="Vestpocket" data-source="post: 240242" data-attributes="member: 4848"><p>This is <strong>not </strong>true.</p><p></p><p>There are <em>zero </em>studies that show antidepressants to be "very effective." At best, there are studies that can show that there is a minimal, marginal effect, when given enough time. A 2018 metastudy showed that the average placebo match for all third generation ADs is 74%, roughly 60% of people receive no positive effect whatsoever from any particular drug, the 1MDR (one month drop-off rate) for SSRIs is 80%(!), and of the <em><strong>minority </strong></em>of people that claim a benefit, it's actually a mere 2-4 points on the rating scale being used (BDI, HDRS, etc.)</p><p></p><p>There has <strong><em>never </em></strong>been a "very effective" antidepressant drug released, to date. We have only marginal efficacy in a minority of takers, with 80% of people dropping them in the first month due to side effects or lack of efficacy, and that number climbing sharply as we get to 2, 3, and 6 months.</p><p></p><p>Funny enough, the effect of exercise (30 minutes walking) actually beats <em>all </em>currently existing anti-depressant drugs on the market when using the same depression rating scales. Not one pharmaceutical on the market today beats a little walking. That's how weak ADs are.</p><p></p><p>There are many studies that show exact placebo matches for popular drugs like Prozac and Wellbutrin (zero effect; I have about 5 bookmarked for Wellbutrin presently), and a very famous 2000 metastudy by an MIT PhD that looked at all the unpublished and contrary studies that were not submitted to journals and concluded that modern anti-depressants have <strong>no </strong>averaged out efficacy against depression whatsoever. (Suggesting that what we see published in journals are mostly the studies that show a lucky 2-3 point bias towards the drug, because we can find just as many that show the placebo control pill <em>winning </em>by the same degree when we look at what was not submitted for publication.)</p><p></p><p>I made the mistake of trying 10 or so different antidepressants over the years. Not one of them had any effect. Placebo. Junk.</p><p></p><p>The 74% placebo match (and some are higher) of antdepressant drugs versus their placebo control shows that the majority of the effect of any of these drugs is raw expectation bias.</p></blockquote><p></p>
[QUOTE="Vestpocket, post: 240242, member: 4848"] This is [B]not [/B]true. There are [I]zero [/I]studies that show antidepressants to be "very effective." At best, there are studies that can show that there is a minimal, marginal effect, when given enough time. A 2018 metastudy showed that the average placebo match for all third generation ADs is 74%, roughly 60% of people receive no positive effect whatsoever from any particular drug, the 1MDR (one month drop-off rate) for SSRIs is 80%(!), and of the [I][B]minority [/B][/I]of people that claim a benefit, it's actually a mere 2-4 points on the rating scale being used (BDI, HDRS, etc.) There has [B][I]never [/I][/B]been a "very effective" antidepressant drug released, to date. We have only marginal efficacy in a minority of takers, with 80% of people dropping them in the first month due to side effects or lack of efficacy, and that number climbing sharply as we get to 2, 3, and 6 months. Funny enough, the effect of exercise (30 minutes walking) actually beats [I]all [/I]currently existing anti-depressant drugs on the market when using the same depression rating scales. Not one pharmaceutical on the market today beats a little walking. That's how weak ADs are. There are many studies that show exact placebo matches for popular drugs like Prozac and Wellbutrin (zero effect; I have about 5 bookmarked for Wellbutrin presently), and a very famous 2000 metastudy by an MIT PhD that looked at all the unpublished and contrary studies that were not submitted to journals and concluded that modern anti-depressants have [B]no [/B]averaged out efficacy against depression whatsoever. (Suggesting that what we see published in journals are mostly the studies that show a lucky 2-3 point bias towards the drug, because we can find just as many that show the placebo control pill [I]winning [/I]by the same degree when we look at what was not submitted for publication.) I made the mistake of trying 10 or so different antidepressants over the years. Not one of them had any effect. Placebo. Junk. The 74% placebo match (and some are higher) of antdepressant drugs versus their placebo control shows that the majority of the effect of any of these drugs is raw expectation bias. [/QUOTE]
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Mental Health
The Case Against Antidepressants
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