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The boron supremacy
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<blockquote data-quote="DragonBits" data-source="post: 106203" data-attributes="member: 18023"><p>You could be right, many studies used 3mg of boron supplement. But other studies used 6 mg, some used 11.6 mg. </p><p> </p><p>But it appeared to me that the studies that showed an effect on SHBG, hsCRP and free T were all at 6 mg up to 11.6 mg.</p><p></p><p></p><p> </p><p>The UL upper limit of boron is 20 mg, but that appears arbitrary. Workers in boric acid production plant averaged 12.6 mg/d, with no adverse effects.</p><p></p><p> </p><p>If you can find evidence that even 12 mgs a day of boron supplement is harmful, I would be interested in reading about it. Some people get upwards of 30 mg a day from their diet.</p><p> </p><p></p><p>I feel leafy vegetables grown in the USA don’t have a lot of boron or magnesium in them, and I while I eat some plants containing boron, I by no means eat a lot.</p><p></p><p>Here are excerpts of studies done on higher levels of boron supplement.</p><p>=====================================</p><p></p><p>Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines.</p><p> </p><p>Boron possesses widespread properties in biochemistry and nutrition. <strong>Acute supplementation with 11.6 mg of boron resulted in a significant increase in plasma boron concentration.</strong></p><p><strong></strong></p><p>Six hours supplementation showed a significant decrease on sex hormone binding globulin (SHBG), high sensitive CRP (hsCRP) and TNF-α level. After one week (in samples taken at 8.00 A.M, only), the mean plasma free testosterone increased and the mean plasma estradiol decreased significantly. Dihydrotestosterone, cortisol and vitamin D was elevated. Also, concentrations of all three inflammatory biomarkers decreased after supplementation. Of note, despite decreased proinflammatory cytokines, based on recent clinical data, this must be the first human study report to show an increase level of free testosterone after boron consumption.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/21129941" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/21129941</a></p><p> </p><p><strong>After only 1 week of boron supplementation of 6 mg/d</strong>, a further study by Naghii et al20 of healthy males (n = 8) found (1) a significant increase in free testosterone, which rose from an average of 11.83 pg/mL to 15.18 pg/mL; and (2) significant decreases in E2, which dropped from 42.33 pg/mL to 25.81 pg/mL. All of the inflammatory biomarkers that were measured also decreased: (1) interleukin (IL) 6, from 1.55 pg/mL to 0.87 pg/mL; (2) high-sensitivity C-reactive protein (hs-CRP) by approximately 50%, a remarkable decrease, from 1460 ng/mL to 795 ng/mL; and (3) tumor necrosis factor α (TNF-α) by approximately 30%, from 12.32 to 9.97 pg/mL. Levels of dihydrotestosterone, cortisol, and vitamin D increased slightly.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/</a></p><p> </p><p>===============================================</p><p></p><p>Of course, it is possible to poison yourself with anything. <strong>A man committed suicide by consuming 2 CUPS of boric acid crystals dissolved in water.</strong></p><p> </p><p> This is the only adult reported to die from acute boric acid ingestion in recent years and may be atypical since the patient was untreated for 3 days and presented with dehydration and renal function impairment. This case suggests that lack of adequate urine flow and dehydration increases the risk of boron toxicity.</p><p> </p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/1388380" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/1388380</a></p><p> </p><p>I was reporting what I did, and I feel 6 mg isn’t going to present any sort of problem and was the dose most likely to have an effect, even 12 mg would be OK but maybe wasteful. And I don’t like to push the boundary that far, as I doubt it would be any more effective. </p><p> </p><p>Boron supplements are cheap, so I chose 6 mg.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 106203, member: 18023"] You could be right, many studies used 3mg of boron supplement. But other studies used 6 mg, some used 11.6 mg. But it appeared to me that the studies that showed an effect on SHBG, hsCRP and free T were all at 6 mg up to 11.6 mg. The UL upper limit of boron is 20 mg, but that appears arbitrary. Workers in boric acid production plant averaged 12.6 mg/d, with no adverse effects. If you can find evidence that even 12 mgs a day of boron supplement is harmful, I would be interested in reading about it. Some people get upwards of 30 mg a day from their diet. I feel leafy vegetables grown in the USA don’t have a lot of boron or magnesium in them, and I while I eat some plants containing boron, I by no means eat a lot. Here are excerpts of studies done on higher levels of boron supplement. ===================================== Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Boron possesses widespread properties in biochemistry and nutrition. [B]Acute supplementation with 11.6 mg of boron resulted in a significant increase in plasma boron concentration. [/B] Six hours supplementation showed a significant decrease on sex hormone binding globulin (SHBG), high sensitive CRP (hsCRP) and TNF-α level. After one week (in samples taken at 8.00 A.M, only), the mean plasma free testosterone increased and the mean plasma estradiol decreased significantly. Dihydrotestosterone, cortisol and vitamin D was elevated. Also, concentrations of all three inflammatory biomarkers decreased after supplementation. Of note, despite decreased proinflammatory cytokines, based on recent clinical data, this must be the first human study report to show an increase level of free testosterone after boron consumption. [URL]https://www.ncbi.nlm.nih.gov/pubmed/21129941[/URL] [B]After only 1 week of boron supplementation of 6 mg/d[/B], a further study by Naghii et al20 of healthy males (n = 8) found (1) a significant increase in free testosterone, which rose from an average of 11.83 pg/mL to 15.18 pg/mL; and (2) significant decreases in E2, which dropped from 42.33 pg/mL to 25.81 pg/mL. All of the inflammatory biomarkers that were measured also decreased: (1) interleukin (IL) 6, from 1.55 pg/mL to 0.87 pg/mL; (2) high-sensitivity C-reactive protein (hs-CRP) by approximately 50%, a remarkable decrease, from 1460 ng/mL to 795 ng/mL; and (3) tumor necrosis factor α (TNF-α) by approximately 30%, from 12.32 to 9.97 pg/mL. Levels of dihydrotestosterone, cortisol, and vitamin D increased slightly. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/[/URL] =============================================== Of course, it is possible to poison yourself with anything. [B]A man committed suicide by consuming 2 CUPS of boric acid crystals dissolved in water.[/B] This is the only adult reported to die from acute boric acid ingestion in recent years and may be atypical since the patient was untreated for 3 days and presented with dehydration and renal function impairment. This case suggests that lack of adequate urine flow and dehydration increases the risk of boron toxicity. [URL]https://www.ncbi.nlm.nih.gov/pubmed/1388380[/URL] I was reporting what I did, and I feel 6 mg isn’t going to present any sort of problem and was the dose most likely to have an effect, even 12 mg would be OK but maybe wasteful. And I don’t like to push the boundary that far, as I doubt it would be any more effective. Boron supplements are cheap, so I chose 6 mg. [/QUOTE]
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