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There are so many variables at play with Clomid (and really any SERM) treatment that complicate the ultimate outcome. These include the zuclomiphene effect, the interaction with E receptors in the CNS (both of these likely play a role in libido changes, either positive or negative), and the varying tissue-specific agonist/antagonist actions of the isomers.

I have guys who LOVE their Clomid regimen and are extremely grateful it has worked well for them...and then as we all see many who either respond subtly or not at all. There is really no way to predict in advance which of those outcomes will be the final result for any given patient (until they actually undergo treatment).