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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Testosterone. Thyroid
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<blockquote data-quote="Vince" data-source="post: 57413" data-attributes="member: 843"><p>Nelson wrote this:</p><p>I have found no paper on the effect of testosterone replacement on TSH, free T3, free T4, etc</p><p></p><p> After reading several papers, my opinion is that TRT has no clinically significant effect on thyroid function in men with normal thyroid unless you block aromatization to estradiol.</p><p></p><p></p><p></p><p> One study showed that the use of an androgen that does not get converted to estradiol affects the way the thyroid gland responds to thyroid releasing hormone (TRH):</p><p></p><p> "Fluoxymesterone, an androgen not converted to estrogen, caused a significant decrease in the TSH response to TRH in 11 men with primary hypogonadism [maximum change in TSH: before treatment, 11.3 ° 0.9 juU/ml (mean ° SE); 8.9 ° 1.0 after 2 weeks (P < 0.001); 8.2 ° 1.1 after6 weeks (P < 0.01)]. There was a significant fall in serum T[SUB]i[/SUB]−binding globulin (TBG) (measured directly by RIA) without a change in the free T[SUB]4[/SUB] or free T[SUB]3[/SUB] index.</p><p><a href="http://press.endocrine.org/doi/abs/10.1210/jcem-52-2-173" target="_blank"><span style="color: #a30706">http://press.endocrine.org/doi/abs/1.../jcem-52-2-173</span></a></p><p></p><p></p><p> This study looked at the effect of hCG (which raises T and E2):</p><p></p><p> After 3 months of hCG treatment, there was a marked rise in serum estradiol as well as testosterone. Serum T4 was reduced without a change in T3, T3 resin uptake, or TBG. Furthermore, there was no alteration in the TSH response to TRH. </p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/6408116" target="_blank"><span style="color: #a30706">http://www.ncbi.nlm.nih.gov/pubmed/6408116</span></a></p><p></p><p></p><p> This study showed the effect of anabolic steroids on thyroid function. However, it does not mention if the were aromatising anabolics or not. My opinion is that estradiol has a normalizing effect on thyroid function. Low E2 may be the cause for these results:</p><p></p><p> During the use of steroids significant decreases (P < 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P < 0.001). In relation to the changes in the thyroid function param eters measured, we suggest that the primary target of androgen action was TBG biosynthesis.</p><p></p><p><a href="http://ajs.sagepub.com/content/15/4/357.short" target="_blank"><span style="color: #a30706">http://ajs.sagepub.com/content/15/4/357.short</span></a> </p><p><a href="https://www.excelmale.com/forum/showthread.php?3950-does-testosterone-replacement-therapy-cause-hypothyroidism" target="_blank">https://www.excelmale.com/forum/showthread.php?3950-does-testosterone-replacement-therapy-cause-hypothyroidism</a></p></blockquote><p></p>
[QUOTE="Vince, post: 57413, member: 843"] Nelson wrote this: I have found no paper on the effect of testosterone replacement on TSH, free T3, free T4, etc After reading several papers, my opinion is that TRT has no clinically significant effect on thyroid function in men with normal thyroid unless you block aromatization to estradiol. One study showed that the use of an androgen that does not get converted to estradiol affects the way the thyroid gland responds to thyroid releasing hormone (TRH): "Fluoxymesterone, an androgen not converted to estrogen, caused a significant decrease in the TSH response to TRH in 11 men with primary hypogonadism [maximum change in TSH: before treatment, 11.3 ° 0.9 juU/ml (mean ° SE); 8.9 ° 1.0 after 2 weeks (P < 0.001); 8.2 ° 1.1 after6 weeks (P < 0.01)]. There was a significant fall in serum T[SUB]i[/SUB]−binding globulin (TBG) (measured directly by RIA) without a change in the free T[SUB]4[/SUB] or free T[SUB]3[/SUB] index. [URL="http://press.endocrine.org/doi/abs/10.1210/jcem-52-2-173"][COLOR=#a30706]http://press.endocrine.org/doi/abs/1.../jcem-52-2-173[/COLOR][/URL] This study looked at the effect of hCG (which raises T and E2): After 3 months of hCG treatment, there was a marked rise in serum estradiol as well as testosterone. Serum T4 was reduced without a change in T3, T3 resin uptake, or TBG. Furthermore, there was no alteration in the TSH response to TRH. [URL="http://www.ncbi.nlm.nih.gov/pubmed/6408116"][COLOR=#a30706]http://www.ncbi.nlm.nih.gov/pubmed/6408116[/COLOR][/URL] This study showed the effect of anabolic steroids on thyroid function. However, it does not mention if the were aromatising anabolics or not. My opinion is that estradiol has a normalizing effect on thyroid function. Low E2 may be the cause for these results: During the use of steroids significant decreases (P < 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P < 0.001). In relation to the changes in the thyroid function param eters measured, we suggest that the primary target of androgen action was TBG biosynthesis. [URL="http://ajs.sagepub.com/content/15/4/357.short"][COLOR=#a30706]http://ajs.sagepub.com/content/15/4/357.short[/COLOR][/URL] [URL]https://www.excelmale.com/forum/showthread.php?3950-does-testosterone-replacement-therapy-cause-hypothyroidism[/URL] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Testosterone. Thyroid
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