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Message: <blockquote data-quote="madman" data-source="post: 288217" data-attributes="member: 13851">Dr. Morgentaler back in action!Listen closely, loved this one![MEDIA=spotify]episode:6aSGmkWeLOYyJ3oWbDNs5I[/MEDIA][ATTACH=full]47468[/ATTACH]Pros/Cons oral TU (51:24-57:12)* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baselineSynopsisDr. Morgentaler starts by sharing his pioneering journey with testosterone replacement therapy starting in the 1980s, challenging long-held beliefs that it increases prostate cancer risk. He highlights key studies to debunk myths about testosterone’s dangers and emphasizes the ability to improve patients’ quality of life. Further, he discusses modern treatment options and provides practical advice for safely initiating testosterone replacement therapy. Finally, he discusses its use in patients with a history of prostate cancer and emphasizes the importance of individualized treatment plans.<h2></h2>Timestamps00:00 - Introduction03:04 - Historical Perspectives on Testosterone and Prostate Cancer21:31 - Evolution of Testosterone Treatments31:16 - Testosterone and Prostate Cancer: A Controversial History35:42 - Treating Prostate Cancer Patients with Testosterone37:12 - A Case Study43:05 - Shifting Perspectives57:15 - Final Thoughts</blockquote>

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038