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Thanks for bringing this up!

In my case, I have low free T (10) and low E2 (5). LDL-P is elevated as is Lp(a), sdLDL-P and APOB. HDL is low normal (43). Not a good profile. Have already taken all the known steps (low carb, niacin, omega 3s, berberine, guggul, etc.) I did not think to consider E2's effect on lipids. It appears sufficient E2 will raise HDL and lower LDL, but too much will cause thrombosis:
http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx

This is where TRT would help kill two birds with one stone as long as I again manage H/H and don't allow too much aromatization (I could actually use some now).

But more confounding is that we know exo T raises LDL-C and lowers HDL-C, but do we know if it raises the good (large particle) LDL or bad (small)?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/

"In men, neither DHEA nor testosterone affected LDL or HDL particle concentrations.":
http://www.ncbi.nlm.nih.gov/pubmed/20139233

<blockquote data-quote="Marco N Cognito" data-source="post: 1949" data-attributes="member: 13">Thanks for bringing this up!In my case, I have low free T (10) and low E2 (5). LDL-P is elevated as is Lp(a), sdLDL-P and APOB. HDL is low normal (43). Not a good profile. Have already taken all the known steps (low carb, niacin, omega 3s, berberine, guggul, etc.) I did not think to consider E2&#039;s effect on lipids. It appears sufficient E2 will raise HDL and lower LDL, but too much will cause thrombosis:<a href="http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx" target="_blank">http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx</a>This is where TRT would help kill two birds with one stone as long as I again manage H/H and don&#039;t allow too much aromatization (I could actually use some now).But more confounding is that we know exo T raises LDL-C and lowers HDL-C, but do we know if it raises the good (large particle) LDL or bad (small)?<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/</a>&quot;In men, neither DHEA nor testosterone affected LDL or HDL particle concentrations.&quot;: <a href="http://www.ncbi.nlm.nih.gov/pubmed/20139233" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/20139233</a></blockquote>

[QUOTE="Marco N Cognito, post: 1949, member: 13"] Thanks for bringing this up! In my case, I have low free T (10) and low E2 (5). LDL-P is elevated as is Lp(a), sdLDL-P and APOB. HDL is low normal (43). Not a good profile. Have already taken all the known steps (low carb, niacin, omega 3s, berberine, guggul, etc.) I did not think to consider E2's effect on lipids. It appears sufficient E2 will raise HDL and lower LDL, but too much will cause thrombosis: [URL]http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx[/URL] This is where TRT would help kill two birds with one stone as long as I again manage H/H and don't allow too much aromatization (I could actually use some now). But more confounding is that we know exo T raises LDL-C and lowers HDL-C, but do we know if it raises the good (large particle) LDL or bad (small)? [url]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/[/url] "In men, neither DHEA nor testosterone affected LDL or HDL particle concentrations.": [url]http://www.ncbi.nlm.nih.gov/pubmed/20139233[/url] [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038