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Thanks for bringing this up!

In my case, I have low free T (10) and low E2 (5). LDL-P is elevated as is Lp(a), sdLDL-P and APOB. HDL is low normal (43). Not a good profile. Have already taken all the known steps (low carb, niacin, omega 3s, berberine, guggul, etc.) I did not think to consider E2's effect on lipids. It appears sufficient E2 will raise HDL and lower LDL, but too much will cause thrombosis:
http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx

This is where TRT would help kill two birds with one stone as long as I again manage H/H and don't allow too much aromatization (I could actually use some now).

But more confounding is that we know exo T raises LDL-C and lowers HDL-C, but do we know if it raises the good (large particle) LDL or bad (small)?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/

"In men, neither DHEA nor testosterone affected LDL or HDL particle concentrations.":
http://www.ncbi.nlm.nih.gov/pubmed/20139233

<blockquote data-quote="Marco N Cognito" data-source="post: 1949" data-attributes="member: 13">Thanks for bringing this up!In my case, I have low free T (10) and low E2 (5). LDL-P is elevated as is Lp(a), sdLDL-P and APOB. HDL is low normal (43). Not a good profile. Have already taken all the known steps (low carb, niacin, omega 3s, berberine, guggul, etc.) I did not think to consider E2&#039;s effect on lipids. It appears sufficient E2 will raise HDL and lower LDL, but too much will cause thrombosis:<a href="http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx" target="_blank">http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx</a>This is where TRT would help kill two birds with one stone as long as I again manage H/H and don&#039;t allow too much aromatization (I could actually use some now).But more confounding is that we know exo T raises LDL-C and lowers HDL-C, but do we know if it raises the good (large particle) LDL or bad (small)?<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/</a>&quot;In men, neither DHEA nor testosterone affected LDL or HDL particle concentrations.&quot;: <a href="http://www.ncbi.nlm.nih.gov/pubmed/20139233" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/20139233</a></blockquote>

[QUOTE="Marco N Cognito, post: 1949, member: 13"] Thanks for bringing this up! In my case, I have low free T (10) and low E2 (5). LDL-P is elevated as is Lp(a), sdLDL-P and APOB. HDL is low normal (43). Not a good profile. Have already taken all the known steps (low carb, niacin, omega 3s, berberine, guggul, etc.) I did not think to consider E2's effect on lipids. It appears sufficient E2 will raise HDL and lower LDL, but too much will cause thrombosis: [URL]http://my.clevelandclinic.org/heart/prevention/estrogen-hormones/default.aspx[/URL] This is where TRT would help kill two birds with one stone as long as I again manage H/H and don't allow too much aromatization (I could actually use some now). But more confounding is that we know exo T raises LDL-C and lowers HDL-C, but do we know if it raises the good (large particle) LDL or bad (small)? [url]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069573/[/url] "In men, neither DHEA nor testosterone affected LDL or HDL particle concentrations.": [url]http://www.ncbi.nlm.nih.gov/pubmed/20139233[/url] [/QUOTE]