ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone shock therapy for prostate cancer
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Pranayama" data-source="post: 56315" data-attributes="member: 13305"><p><span style="color: #333333"><p style="margin-left: 40px"></p></span></p><p style="margin-left: 40px"><span style="color: #333333">Interesting results from "shocking" prostate cancer cells with testosterone. </p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p></span></p><p style="margin-left: 40px"><span style="color: #333333">Telegraph.co.uk: A man with advanced<a href="http://www.telegraph.co.uk/news/2016/09/14/prostate-cancer-survival-rates-equally-high-if-you-monitor-disea/" target="_blank"> prostate cancer </a>is believed to be cured after doctors 'shocked' his tumour to death with huge amounts of testosterone.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">The result has been described as 'unexpected' and 'exciting' because most prostate cancer therapies work by depriving tumours of testosterone, because cancer uses it as a fuel.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">Other seriously ill men taking part in the same trial showed responses that astounded scientists, with tumours shrinking and the progress of their disease halted. </p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p></span></p><p style="margin-left: 40px"><span style="color: #333333">Levels of Prostate Specific Antigen (PSA), a blood marker used to monitor prostate cancer, also fell in the majority of the 47 participants.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">One individual whose PSA levels dropped to zero after three months and shows no remaining trace of the disease after 22 cycles of treatment appears to be cured, said the researchers. </p></span></p><p style="margin-left: 40px"><span style="color: #333333">Professor Sam Denmeade, from <a href="http://www.hopkinsmedicine.org/som/" target="_blank">Johns Hopkins University School of Medicine</a> in Baltimore, US, who led the study, said: ""Our goal is to shock the cancer cells by exposing them rapidly to very high followed by very low levels of testosterone in the blood. The results are unexpected and exciting. </p></span></p><p style="margin-left: 40px"><span style="color: #333333">"We are still in the early stages of figuring out how this works and how to incorporate it into the treatment paradigm for prostate cancer.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">"Many of the men have stable disease that has not progressed for more than 12 months.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">"I think we may have cured one man whose PSA dropped to zero after three months and has remained so now for 22 cycles. His disease has all disappeared."</p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p><p></span></p><p><span style="color: #333333"><p style="margin-left: 40px">All of the patients had spreading cancer that was resistant to treatment with two of the latest hormone therapy drugs, abiraterone and enzalutamide.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">The trial involved three cycles of "bipolar androgen therapy" (BAT) which involves alternately flooding and starving the body of the male hormone testosterone.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">The treatment is revolutionary because testosterone is generally assumed to fuel prostate cancer. For decades men with advanced and spreading prostate cancer have been treated by cutting off the supply of testosterone or blocking its effects.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">In contrast upping testosterone in a man with prostate cancer is generally considered similar to pouring petrol on a fire.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">Yet laboratory experiments had hinted that blasting tumours with high levels of the hormone might suppress or even kill prostate cancer cells.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">The men received high dose injections of testosterone once every 28 days. At the same time, they were given a drug that stopped testosterone being produced naturally by the testicles.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">Prof Denmeade said it was still not clear how the treatment worked, but it appeared to involve cell signalling and part of the process of cell division. Large doses of testosterone also seemed to cause prostate cancer cells to make breaks in their DNA.</p></span></p><p style="margin-left: 40px"><span style="color: #333333">Cancer cells stopped dividing and turned "senescent", meaning they "become like old men who sit around and tell stories but don't make much trouble", said the professor.</p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p></span></p><p style="margin-left: 40px"><span style="color: #333333"></p><p></span></p></blockquote><p></p>
[QUOTE="Pranayama, post: 56315, member: 13305"] [COLOR=#333333][FONT=Austin News Text Semibold][INDENT=2][FONT=Austin News Text Roman] Interesting results from "shocking" prostate cancer cells with testosterone. Telegraph.co.uk: A man with advanced[URL="http://www.telegraph.co.uk/news/2016/09/14/prostate-cancer-survival-rates-equally-high-if-you-monitor-disea/"] prostate cancer [/URL]is believed to be cured after doctors 'shocked' his tumour to death with huge amounts of testosterone.[/FONT] [FONT=Austin News Text Roman]The result has been described as 'unexpected' and 'exciting' because most prostate cancer therapies work by depriving tumours of testosterone, because cancer uses it as a fuel.[/FONT] [FONT=Austin News Text Roman]Other seriously ill men taking part in the same trial showed responses that astounded scientists, with tumours shrinking and the progress of their disease halted. [/FONT] [FONT=Austin News Text Roman]Levels of Prostate Specific Antigen (PSA), a blood marker used to monitor prostate cancer, also fell in the majority of the 47 participants.[/FONT] [FONT=Austin News Text Roman]One individual whose PSA levels dropped to zero after three months and shows no remaining trace of the disease after 22 cycles of treatment appears to be cured, said the researchers. [/FONT] [FONT=Austin News Text Roman]Professor Sam Denmeade, from [URL="http://www.hopkinsmedicine.org/som/"]Johns Hopkins University School of Medicine[/URL] in Baltimore, US, who led the study, said: ""Our goal is to shock the cancer cells by exposing them rapidly to very high followed by very low levels of testosterone in the blood. The results are unexpected and exciting. [/FONT] [FONT=Austin News Text Roman]"We are still in the early stages of figuring out how this works and how to incorporate it into the treatment paradigm for prostate cancer.[/FONT] [FONT=Austin News Text Roman]"Many of the men have stable disease that has not progressed for more than 12 months.[/FONT] [FONT=Austin News Text Roman]"I think we may have cured one man whose PSA dropped to zero after three months and has remained so now for 22 cycles. His disease has all disappeared."[/FONT] [/INDENT] [/FONT][/COLOR] [COLOR=#333333][FONT=Austin News Text Semibold][INDENT=2][FONT=Austin News Text Roman]All of the patients had spreading cancer that was resistant to treatment with two of the latest hormone therapy drugs, abiraterone and enzalutamide.[/FONT] [FONT=Austin News Text Roman]The trial involved three cycles of "bipolar androgen therapy" (BAT) which involves alternately flooding and starving the body of the male hormone testosterone.[/FONT] [FONT=Austin News Text Roman]The treatment is revolutionary because testosterone is generally assumed to fuel prostate cancer. For decades men with advanced and spreading prostate cancer have been treated by cutting off the supply of testosterone or blocking its effects.[/FONT] [FONT=Austin News Text Roman]In contrast upping testosterone in a man with prostate cancer is generally considered similar to pouring petrol on a fire.[/FONT] [FONT=Austin News Text Roman]Yet laboratory experiments had hinted that blasting tumours with high levels of the hormone might suppress or even kill prostate cancer cells.[/FONT] [FONT=Austin News Text Roman]The men received high dose injections of testosterone once every 28 days. At the same time, they were given a drug that stopped testosterone being produced naturally by the testicles.[/FONT] [FONT=Austin News Text Roman]Prof Denmeade said it was still not clear how the treatment worked, but it appeared to involve cell signalling and part of the process of cell division. Large doses of testosterone also seemed to cause prostate cancer cells to make breaks in their DNA.[/FONT] [FONT=Austin News Text Roman]Cancer cells stopped dividing and turned "senescent", meaning they "become like old men who sit around and tell stories but don't make much trouble", said the professor.[/FONT] [/INDENT] [/FONT][/COLOR] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone shock therapy for prostate cancer
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top