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Testosterone Replacement Therapy (TRT) Effect on Men's Fertility
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<blockquote data-quote="Nelson Vergel" data-source="post: 272896" data-attributes="member: 3"><p><em>Testosterone Replacement Therapy (TRT) Effect on Men's Fertility</em></p><p></p><p>[caption id="attachment_5193" align="aligncenter" width="300"]<img src="http://articles.excelmale.com/wp-content/uploads/espermatogénesis-300x188.jpg" class="bbImage" alt="" data-url="http://articles.excelmale.com/wp-content/uploads/espermatogénesis-300x188.jpg" style="" /> men fertility sperm[/caption]</p><p></p><p>Testosterone replacement therapy suppresses spermatogenesis (sperm production) by reducing intratesticular testosterone and decreasing FSH through suppression of the hypothalamic-pituitary-gonadal axis (HPGA). Conflicting evidence exists for the long-term risk to fertility in men on TRT. Data abstracted from trials which sought to utilize TRT as a contraceptive found that sperm concentrations were suppressed to less than 1 x 106 ml-1 within 3.5 months. After discontinuation of testosterone, projected time to recovery (20 x 106 ml-1) was 67%, 90%, 96%, and 100% at 6, 12, 16, and 24 months respectively.</p><p></p><p>A recent publication evaluating men who presented to an infertility clinic with a history of TRT use found that only 70% of men achieved sperm recovery (total motile count &gt;5 x 106) and that increased age and duration of TRT use were negative predictors of a patient’s ability to return to fertility. This data is likely overestimates the long-term detrimental effect of TRT on fertility as no information regarding the patients’ ability to produce sperm before TRT is available. While a subset of these men was likely infertile prior to TRT therapy, this data serves as a caution to men and practitioners considering TRT within their reproductive years. While the absolute percentage of men who experience irreversible fertility loss after undergoing TRT is not known, there is a significant concern for this side effect in young men who may ultimately desire to father a child.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/m/pubmed/30131284/" target="_blank">Reference</a></p><p></p><p>More <a href="https://www.google.com/search?q=fertility+excelmale.com+site:www.excelmale.com&amp;rlz=1C1CHBF_enUS800US800&amp;sa=X&amp;ved=2ahUKEwjroa2o_KHdAhUPlKwKHTlwClYQrQIoBDABegQICRAM&amp;biw=1920&amp;bih=943" target="_blank">articles on men's fertility</a> on ExcelMale.com</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 272896, member: 3"] [i]Testosterone Replacement Therapy (TRT) Effect on Men's Fertility[/i] [caption id="attachment_5193" align="aligncenter" width="300"][img]http://articles.excelmale.com/wp-content/uploads/espermatogénesis-300x188.jpg[/img] men fertility sperm[/caption] Testosterone replacement therapy suppresses spermatogenesis (sperm production) by reducing intratesticular testosterone and decreasing FSH through suppression of the hypothalamic-pituitary-gonadal axis (HPGA). Conflicting evidence exists for the long-term risk to fertility in men on TRT. Data abstracted from trials which sought to utilize TRT as a contraceptive found that sperm concentrations were suppressed to less than 1 x 106 ml-1 within 3.5 months. After discontinuation of testosterone, projected time to recovery (20 x 106 ml-1) was 67%, 90%, 96%, and 100% at 6, 12, 16, and 24 months respectively. A recent publication evaluating men who presented to an infertility clinic with a history of TRT use found that only 70% of men achieved sperm recovery (total motile count >5 x 106) and that increased age and duration of TRT use were negative predictors of a patient’s ability to return to fertility. This data is likely overestimates the long-term detrimental effect of TRT on fertility as no information regarding the patients’ ability to produce sperm before TRT is available. While a subset of these men was likely infertile prior to TRT therapy, this data serves as a caution to men and practitioners considering TRT within their reproductive years. While the absolute percentage of men who experience irreversible fertility loss after undergoing TRT is not known, there is a significant concern for this side effect in young men who may ultimately desire to father a child. [url=https://www.ncbi.nlm.nih.gov/m/pubmed/30131284/]Reference[/url] More [url=https://www.google.com/search?q=fertility+excelmale.com+site:www.excelmale.com&rlz=1C1CHBF_enUS800US800&sa=X&ved=2ahUKEwjroa2o_KHdAhUPlKwKHTlwClYQrQIoBDABegQICRAM&biw=1920&bih=943]articles on men's fertility[/url] on ExcelMale.com [/QUOTE]
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